2-(3,5-Dihydroxy-4-methoxyphenyl)-6-(3,7-dimethylocta-2,6-dienyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,5-Dihydroxy-4-methoxyphenyl)-6-(3,7-dimethylocta-2,6-dienyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one
• 英文别名: 2-(3,5-dihydroxy-4-methoxyphenyl)-6-(3,7-dimethylocta-2,6-dienyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one
• 化学式: C₂₆H₃₀O₇
• 分子量: 454.5
• InChiKey: GMGRYHOHJJROMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY

  公开号：US10406136B2

  公开（公告）日：2019-09-10

  The present invention relates to a composition for suppressing neuraminidase activity comprising a geranylated flavonoid derived from Paulownia tomentosa as an active ingredient. The Paulownia tomentosa extract and the geranylated flavonoid isolated therefrom exhibit an effect in significantly suppressing neuraminidase, which is an enzyme that plays an important role in the occurrence of pathogenic viral and bacterial infections and of the inflammation that accompanies such infection, and thus the Paulownia tomentosa extract or the geranylated flavonoid isolated therefrom can advantageously be used as an active ingredient in a composition for inhibiting neuraminidase activity.

  本发明涉及一种抑制神经氨酸酶活性的组合物，该组合物包含一种从泡桐中提取的香叶黄酮类化合物作为活性成分。神经氨酸酶是一种在致病性病毒和细菌感染以及伴随这种感染的炎症发生中起重要作用的酶，因此，泡桐提取物或从中分离出的香叶黄酮类化合物可以作为一种有效成分用于抑制神经氨酸酶活性的组合物中。
• COMPOSITION FOR SUPPRESSING NEURAMINIDASE ACTIVITY COMPRISING GERANYLATED FLAVONOID DERIVED FROM PAULOWNIA TOMENTOSA AS ACTIVE INGREDIENT
  申请人：INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY

  公开号：US20160250179A1

  公开（公告）日：2016-09-01

  The present invention relates to a composition for suppressing neuraminidase activity comprising a geranylated flavonoid derived from Paulownia tomentosa as an active ingredient. The Paulownia tomentosa extract and the geranylated flavonoid isolated therefrom exhibit an effect in significantly suppressing neuraminidase, which is an enzyme that plays an important role in the occurrence of pathogenic viral and bacterial infections and of the inflammation that accompanies such infection, and thus the Paulownia tomentosa extract or the geranylated flavonoid isolated therefrom can advantageously be used as an active ingredient in a composition for inhibiting neuraminidase activity.