6β-(2-ethoxy-naphthalene-1-carbonylamino)-penicillanic acid | 147-52-4

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6β-(2-ethoxy-naphthalene-1-carbonylamino)-penicillanic acid
• 英文别名: 1-<(2'-Aethoxy)-Naphthyl>-Penicillin；2-Ethoxy-naphthamido-penicillin；Nafcillin-1；Naphzillin；(2-ethoxy-naphthalen-1-yl)-penicillin；naphcillin；4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2alpha,5alpha,6beta)]-；6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 147-52-4
• 化学式: C₂₁H₂₂N₂O₅S
• 分子量: 414.482
• InChiKey: GPXLMGHLHQJAGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  714.1±60.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  6

ADMET

毒理性

• 在妊娠和哺乳期间的影响

◉ 母乳喂养期间使用总结：尽管没有关于在哺乳期间使用萘夫西林的信息，但青霉素类药物通常被认为不会对哺乳婴儿造成不良影响。偶尔有报道称青霉素会破坏婴儿的胃肠道菌群，导致腹泻或鹅口疮，但这些影响尚未得到充分评估。萘夫西林在哺乳期母亲中是可以接受的。 ◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。 ◉ 对泌乳和母乳的影响：截至修订日期，没有找到相关的已发布信息。

◉ Summary of Use during Lactation:Although no information is available on the use of nafcillin during breastfeeding, penicillins are generally not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Nafcillin is acceptable in nursing mothers. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)

文献信息

• Electrostatically self-assembled antimicrobial coating for medical applications
  申请人：Akhave R. Jay

  公开号：US20050152955A1

  公开（公告）日：2005-07-14

  A electrostatically self-assembled coating having a biologically active agent incorporated therein is provided. More particularly, a wound dressing having an antimicrobial coating within the dressing construction wherein an antimicrobial agent is released from the dressing over a period of time is produced using a layer-by-layer deposition process.
• US5098417A
  申请人：——

  公开号：US5098417A

  公开（公告）日：1992-03-24
• [EN] ELECTROSTATICALLY SELF-ASSEMBLED ANTIMICROBIAL COATING FOR MEDICAL APPLICATIONS<br/>[FR] REVETEMENT ANTIMICROBIEN AUTOASSEMBLE DE MANIERE ELECTROSTATIQUE POUR APPLICATIONS MEDICALES
  申请人：AVERY DENNISON CORP

  公开号：WO2005058199A1

  公开（公告）日：2005-06-30

  A electrostatically self-assembled coating having a biologically active agent incorporated therein is provided. More particularly, a wound dressing having an antimicrobial coating within the dressing construction wherein an antimicrobial agent is released from the dressing over a period of time is produced using a layer-by-layer deposition process.