2',3',4',3,4-Pentahydroxychalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2',3',4',3,4-Pentahydroxychalcone
• 英文别名: 3-(3,4-dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-one
• 化学式: C₁₅H₁₂O₆
• 分子量: 288.25
• InChiKey: GSBNFGRTUCCBTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Remedies
  申请人：——

  公开号：US20030144316A1

  公开（公告）日：2003-07-31

  The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

  本发明提供了一种治疗剂或预防剂，用于需要增强神经生长因子产生的疾病，用于增强神经生长因子产生的增强剂，或用作增强神经生长因子产生的食品、饮料或饲料，每种包含一种有效成分，即具有增强神经生长因子产生活性的指定化合物或其盐；一种增强神经生长因子产生的方法，包括向哺乳动物投与上述化合物或其盐；以及使用上述化合物或其盐制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，增强神经生长因子产生的增强剂，或用于增强神经生长因子产生的食品、饮料或饲料。此外，本发明提供了具有增强神经生长因子产生活性的新化合物。
• REMEDIES
  申请人：TAKARA BIO INC.

  公开号：EP1254658A1

  公开（公告）日：2002-11-06

  The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

  本发明提供了一种用于需要增强神经生长因子产生的疾病的治疗剂或预防剂，一种用于增强神经生长因子产生的增强剂，或一种用于增强神经生长因子产生的食品、饮料或饲料，每一种都包含作为有效成分的具有增强神经生长因子产生活性的特定化合物或其盐；一种增强神经生长因子生成的方法，包括向哺乳动物施用上述化合物或其盐；以及上述化合物或其盐在制备需要增强神经生长因子生成的疾病的治疗剂或预防剂、神经生长因子生成增强剂或增强神经生长因子生成的食品、饮料或饲料中的用途。此外，本发明还提供了具有增强神经生长因子生成活性的新型化合物。
• Methods and compositions to prevent addiction
  申请人：FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US11045465B2

  公开（公告）日：2021-06-29

  Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject comprising, administering a therapeutic amount of the neurological stimulant and administering an antagonist of the kappa opioid receptor, to thereby reduce or prevent the development of aversion to the CNS stimulant in the subject. Also disclosed is a method of reducing or preventing the development of addiction to a CNS stimulant in a subject, comprising, administering the CNS stimulant and administering a mu opioid receptor antagonist to thereby reduce or prevent the development of addiction to the CNS stimulant in the subject. Also disclosed are pharmaceutical compositions comprising a central nervous system stimulant and an opioid receptor antagonist. Examples of central nervous system stimulants (such as methylphenidate) and opioid receptor antagonists (such as naltrexone) are provided.

  本文公开了一种减少或防止受试者对中枢神经系统兴奋剂产生厌恶感的方法，包括施用治疗量的神经兴奋剂和施用卡巴阿片受体拮抗剂，从而减少或防止受试者对中枢神经系统兴奋剂产生厌恶感。还公开了一种减少或防止受试者对中枢神经刺激物成瘾的方法，包括施用中枢神经刺激物和施用μ阿片受体拮抗剂，从而减少或防止受试者对中枢神经刺激物成瘾。还公开了包含中枢神经系统兴奋剂和阿片受体拮抗剂的药物组合物。提供了中枢神经系统兴奋剂（如哌醋甲酯）和阿片受体拮抗剂（如纳曲酮）的实例。
• REMEDIES FOR THE TREATMENT OF NERVE DIORDERS
  申请人：TAKARA BIO INC.

  公开号：EP1254658B1

  公开（公告）日：2008-09-24
• USE OF OPIOID RECEPTOR ANTAGONISTS
  申请人：DSM IP Assets B.V.

  公开号：EP1926490A2

  公开（公告）日：2008-06-04