N,N,2,5-tetramethylaniline | 17327-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N,2,5-tetramethylaniline
• 英文别名: 2,5-Dimethyl-N,N-dimethyl-anilin；N,N,2,5-Tetramethyl-anilin；2,5-N,N-Tetramethylaniline
• CAS: 17327-77-4
• 化学式: C₁₀H₁₅N
• 分子量: 149.236
• InChiKey: RAXZICBKEQDBNQ-UHFFFAOYSA-N

物化性质

• 熔点：
  235 °C
• 沸点：
  73-74 °C(Press: 0.5 Torr)
• 密度：
  0.932±0.06 g/cm3(Predicted)
• 保留指数：
  1511.5

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N,2,5-tetramethylaniline 在 盐酸 作用下， 生成 4-hydroxymethyl-2,5,N,N,N-pentamethyl-anilinium; iodide
  参考文献：
  名称：

  v.Braun; Arkuszewski; Koehler, Chemische Berichte, 1918, vol. 51, p. 295

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-1,4-二甲基苯 、 二甲胺 在 [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以81%的产率得到N,N,2,5-tetramethylaniline
  参考文献：
  名称：

  Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine

  摘要：

  Simple and efficient Procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a Strong base, t-BuXPhos is employed as the supporting ligand; at 110 degrees C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L,Pd(0). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.137

文献信息

• Light-promoted N,N-dimethylation of amine and nitro compound with methanol catalyzed by Pd/TiO₂ at room temperature
  作者：Lina Zhang、Yan Zhang、Youquan Deng、Feng Shi

  DOI：10.1039/c4ra13848a

  日期：——

  The N,N-dimethylation of different amines and nitro compounds with methanol were realized under UV irradiation at room temperature catalyzed by Pd/TiO₂.

  不同胺类和硝基化合物在室温下经Pd/TiO₂催化，通过紫外辐射实现了甲醇的N，N-二甲基化。
• Synthesis of New Sterically Hindered Anilines
  作者：Barry R. Steele、Spyros Georgakopoulos、Maria Micha-Screttas、Constantinos G. Screttas

  DOI：10.1002/ejoc.200700233

  日期：2007.7

  molecules containing sterically demandingalkyl groups feature in a number of important areas ofchemistry, such as homogeneous catalysis, materials chemis-try, medicinal chemistry, unsaturated and low-coordinationcompounds of the heavier main group elements. Of the vari-ous classes of aromatic compounds, the 2,6-dialkylanilinesfeature widely as starting materials for the synthesis ofSchiff bases, N-heterocyclic

  含有空间要求高的烷基的芳族分子在化学的许多重要领域具有特征，例如均相催化、材料化学、药物化学、较重主族元素的不饱和和低配位化合物。在各种芳香族化合物中，2,6-二烷基苯胺广泛用作合成席夫碱、N-杂环卡宾和金属配合物的相关配体的起始材料，特别是那些用于非均相催化的化合物。由于它们随时可用，除了苯胺
• COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
  申请人：BioTheryX, Inc.

  公开号：US20180170948A1

  公开（公告）日：2018-06-21

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

  本发明提供了调节蛋白功能的化合物，以恢复蛋白稳态，包括细胞因子、CK1α、GSPT1、艾奥洛斯和/或伊卡洛斯活性和细胞间粘附。该发明提供了一种调节蛋白介导的疾病的方法，如细胞因子介导的疾病、障碍、状况或反应。提供了包括与其他细胞因子和炎症介质结合的组合物。提供了治疗、改善或预防与蛋白相关的疾病、障碍或状况的方法，包括与细胞因子相关的疾病、障碍和状况，包括炎症、纤维肌痛、类风湿性关节炎、骨关节炎、强直性脊柱炎、银屑病、银屑病关节炎、炎症性肠病、克罗恩病、溃疡性结肠炎、葡萄膜炎、炎症性肺病、慢性阻塞性肺病、阿尔茨海默病和癌症。
• Addressing Challenges in Palladium-Catalyzed Cross-Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines
  作者：Pamela G. Alsabeh、Mark Stradiotto

  DOI：10.1002/anie.201303305

  日期：2013.7.8

  Mor(DalPhos) for Me(sylates): Described are the first examples of ketone mono‐α‐arylation and primary aliphatic amine monoarylation employing aryl methanesulfonate coupling partners. A range of functionalized aryl mesylates were employed with dialkyl ketones, and also with primary and secondary amines as well as the otherwise challenging coupling partners acetone and methylamine. Ad=adamantyl.

  甲基（甲酸酯）的Mor（DalPhos）：描述了使用甲磺酸甲磺酸酯偶合伙伴进行酮单α-芳基化和脂肪族伯胺单芳基化的第一个实例。与二烷基酮，伯胺和仲胺以及否则具有挑战性的偶联伙伴丙酮和甲胺一起使用了一系列官能化的甲磺酸烷基酯。Ad =金刚烷基。
• [EN] ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME<br/>[FR] ANTIMICROBIENS ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：MELINTA THERAPEUTICS INC

  公开号：WO2017193023A1

  公开（公告）日：2017-11-09

  The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

  本公开涉及抗微生物化合物领域以及制备和使用这些化合物的方法。这些化合物对于治疗、预防、减少人类和动物微生物感染的风险以及延缓微生物感染的发生都是有用的。在某些实施例中，本公开提供一种化合物的化学式(I)：或其互变异构体或该化合物或互变异构体的药用可接受盐。