2-(2,4-Dihydroxyphenyl)-3,5-dihydroxy-8,8-dimethylpyrano[2,3-h]chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(2,4-Dihydroxyphenyl)-3,5-dihydroxy-8,8-dimethylpyrano[2,3-h]chromen-4-one
• 英文别名: 2-(2,4-dihydroxyphenyl)-3,5-dihydroxy-8,8-dimethylpyrano[2,3-h]chromen-4-one
• 化学式: C₂₀H₁₆O₇
• 分子量: 368.343
• InChiKey: HCSHWQRJVZRCCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(2,4-Dihydroxyphenyl)-3,5-dihydroxy-8,8-dimethylpyrano[2,3-h]chromen-4-one 、 三甲基硅烷化重氮甲烷 以 甲醇 为溶剂， 以6.6 mg的产率得到
  参考文献：
  名称：

  Prenylated Flavonoids from the Roots of Desmodium caudatum and Evaluation of Their Antifungal Activity

  摘要：

  Two new prenylated flavonoids (1, 4) and two new prenylated C-methyl-flavonoids (6, 7), together with four known flavonoids (2, 3, 5, 8), were isolated from the roots of Desmodium caudatum. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antifungal activities of five compounds (1, 2, 4, 6, 8) as well as nine flavonoids (9-17) previously isolated from this plant against Aspergillus niger, Penicillium sp., Rhizopus sp., and Trichophyton sp. were evaluated. Compound 6 showed potent antifungal activity against Trichophyton sp. with a minimum inhibitory concentration (MIC) value of 1.95 mu g/mL.

  DOI：

  10.1055/s-0032-1315391