ZINC04831336 | 474-57-7

• 物质功能分类: 原料药 - 消化系统用药 - 利胆药
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ZINC04831336
• 英文别名: 3β-Hydroxy-chol-5-ensaeure；3-Hydroxychol-5-en-24-oic acid；4-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
• CAS: 474-57-7；5255-17-4；111900-81-3；122441-63-8
• 化学式: C₂₄H₃₈O₃
• 分子量: 374.564
• InChiKey: HIAJCGFYHIANNA-UHFFFAOYSA-N

物化性质

• 熔点：
  232°C
• 沸点：
  522.8±23.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)
• 溶解度：
  二恶烷（微溶，超声处理）、DMF（轻微溶解）、DMSO（微溶、加热、超声处理）
• 稳定性/保质期：

  在常温常压下，该物质保持稳定。

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 储存条件：
  常温下应存放在避光、阴凉干燥处，并密封保存。

制备方法与用途

生物活性的3β-羟基-5胆烯酸是内源性的单羟基胆汁酸，在胎儿期的生物体液中已被发现。其靶点为人内源性代谢物。

文献信息

• POLYMER-CARBOHYDRATE-LIPID CONJUGATES
  申请人：Wu Nian

  公开号：US20120202890A1

  公开（公告）日：2012-08-09

  The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.

  该发明包括化合物、制备方法和使用方法。这些化合物可能具有一个主干和三个附加的功能基团：一个脂质基团、一个亲水性聚合物基团和一个碳水化合物基团。特定的功能基团可以根据在制备药物、化妆品、营养保健品等方面的具体应用而选择。还可以选择各种连接剂来优化主干和功能基团之间的性能。
• Novel Compound and Functional Luminescent Probe Comprising the Same
  申请人：Tobita Seiji

  公开号：US20110201802A1

  公开（公告）日：2011-08-18

  Disclosed is a compound characterized by comprising a linker, an oxygen-concentration-responsive phosphorophore which is linked to a first end of the linker, and a fluorophore which is lined to a second end of the linker. In the compound, it is preferred that the triplet level of the phosphorophore be lower than that of the fluorophore. The compound can be used as an oxygen-responsive luminescent probe.

  本发明涉及一种化合物，其特征在于包含一个连接体、一个与连接体的第一端连接的氧浓度响应性荧光团和一个与连接体的第二端连接的荧光团。在该化合物中，优选是荧光团的三重态能级低于荧光团。该化合物可用作氧响应性荧光探针。
• HIGHLY MONODISPERSE BRANCHED PEG-LIPID CONJUGATES
  申请人：Wu Nian

  公开号：US20120232169A1

  公开（公告）日：2012-09-13

  (PEG)-lipid conjugates and methods of preparation are disclosed herein. Methods of preparation may involve stepwise addition of small PEG oligomers to a glycerol backbone until a desired chain size is attained. Polymers resulting from the syntheses may be highly monodisperse. The resulting polymers may comprise branched polyethyleneglycol (PEG)-lipid conjugates. The present disclosure may provide several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method may be suitable for preparing a wide range of conjugates such as PEG lipid conjugates having a glycerol-like central backbone covalently attached to two or more monodisperse PEG chains and a lipid comprising a range of diesters made from fatty acids or bile acids.

  本文揭示了(PEG)-脂质共轭物及其制备方法。制备方法可能涉及将小的PEG寡聚体逐步添加到甘油骨架中，直到达到所需的链长。合成产物可能具有高度单分散性。所得的聚合物可能包括分支的聚乙二醇(PEG)-脂质共轭物。本公开可能提供多种优点，如简化合成、高产率和低起始材料成本。本合成方法可能适用于制备各种共轭物，如具有类甘油中心骨架的PEG脂质共轭物，其与两个或更多单分散PEG链和脂质共价连接，并包含一系列由脂肪酸或胆汁酸制成的二酯。
• Cell membrane-mimicking brush polymer and method for preparding same
  申请人：CEKO CO., LTD.

  公开号：US10907068B2

  公开（公告）日：2021-02-02

  The present invention relates to a cell membrane-mimicking brush polymer having surface properties mimicking a cell membrane and a self-assembly capability by means of a cell membrane mimicking functional group introduced to a brush terminal, and a method for preparing same.

  本发明涉及一种模拟细胞膜的刷状聚合物，它具有模拟细胞膜的表面特性，并且通过在刷状末端引入模拟细胞膜的官能团而具有自组装能力，本发明还涉及一种制备方法。
• Opthalmic compositions of cyclosporin
  申请人：Wu Nian

  公开号：US20110033527A1

  公开（公告）日：2011-02-10

  Lipid-polymer compounds are used to solubilize cyclosporin. Diacylglycerol-polyethyleneglycols (DAG-PEGs) are especially useful in this regard. A preferred embodiment of the invention is an aqueous solution of cyclosporin suitable for opthalmic use.