acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-hydroxy-tetrahydro-pyran-4-yl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-hydroxy-tetrahydro-pyran-4-yl ester
• 英文别名: [3,4,5-Tris(acetyloxy)-6-hydroxyoxan-2-yl]methyl acetate；(3,4,5-triacetyloxy-6-hydroxyoxan-2-yl)methyl acetate
• 化学式: C₁₄H₂₀O₁₀
• 分子量: 348.307
• InChiKey: IEOLRPPTIGNUNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-hydroxy-tetrahydro-pyran-4-yl ester 在 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.67h， 生成
  参考文献：
  名称：

  CN116410220

  摘要：

  公开号：
• 作为产物：
  描述：

  glucose pentaacetate 在 乙酸肼 作用下， 以 N,N-dimethyl-d₆-formamide 为溶剂， 以97 %的产率得到acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-hydroxy-tetrahydro-pyran-4-yl ester
  参考文献：
  名称：

  CN116410220

  摘要：

  公开号：

文献信息

• ARYL HYDROCARBON RECEPTOR MODULATOR
  申请人：Ariagen, Inc.

  公开号：US20190307731A1

  公开（公告）日：2019-10-10

  Disclosed is an aryl hydrocarbon receptor modulator of formula (I), and a pharmaceutically acceptable salt thereof, wherein R′ is H, CN, CH 2 (OH)R 0 , C m H 2m+1 , C n H 2n-1 , C n H 2n-3 , two R a are independently H or two R a together form ═O or ═N—W 3 —R 1 ; A is a C 6 to C 10 aromatic ring unsubstituted or substituted with 1 to 3 R, or a C 2 -C 10 heteroaromatic ring interrupted by 1 to 5 heteroatoms selected from N, O, and S or a 4 to 7 membered nonaromatic heterocyclic ring containing C═N and interrupted by 1 to 3 heteroatoms selected from N, O, and S, with either one unsubstituted or substituted with 1 to 3 R; Q is R, or is a C 6 to C 10 aromatic ring or a C 2 to C 10 heteroaromatic ring unsubstituted or substituted with 1 to 3 R and interrupted by 1 to 5 heteroatoms selected from N, O, and S; and R is R c which is C-attached or R N which is N-attached. The compounds of formula (I) of the present invention can regulate AhR activity, and can be used to inhibit the growth of cancer cells and inhibit the metastasis and invasion of tumor cells.

  本发明揭示了一种化学式（I）的芳香烃受体调节剂及其药用可接受盐，其中R′为H、CN、CH2（OH）R0、CmH2m+1、CnH2n-1、CnH2n-3，两个Ra独立地为H或两个Ra共同形成═O或═N—W3—R1；A为未取代或取代1至3个R的C6至C10芳香环，或由N、O和S中选择的1至5个杂原子中断的C2-C10杂芳环，或含有C═N并由N、O和S中选择的1至3个杂原子中断的4至7个成员的非芳杂环，其中一个未取代或取代1至3个R；Q为R，或者是未取代或取代1至3个R并由N、O和S中断的C6至C10芳香环或C2至C10杂芳环；R为C-连接的Rc或N-连接的RN。本发明的化合物可以调节AhR活性，可用于抑制癌细胞的生长，以及抑制肿瘤细胞的转移和侵袭。
• Novel compounds and methods
  申请人：PharmAxis Pty Ltd.

  公开号：US20030176363A1

  公开（公告）日：2003-09-18

  The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.

  本发明提供了磷酸四氢吡喃化合物及其在治疗依赖于T淋巴细胞迁移的疾病或症状中的用途，以及含有该类化合物的组合物。
• NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT COMPRISING THE SAME
  申请人：BIOMETRIX TECHNOLOGY INC

  公开号：US20210300959A1

  公开（公告）日：2021-09-30

  According to the present invention, there are provided a benzimidazole carbamate-sugar compound conjugate compound represented by the following Chemical Formula 1, a preparation method thereof, and a use thereof as an anti-cancer agent: Wherein, R 1 , R 2 , R 3 and X are as defined in the specification and claims.

  根据本发明，提供了一种由以下化学式1表示的苯并咪唑氨酯-糖化合物共轭物，其制备方法以及作为抗癌剂的用途：其中，R1、R2、R3和X如规范和权利要求中所定义。
• Reagents And Methods For The Formation Of Disulfide Bonds And The Glycosylation Of Proteins
  申请人：Davis Guy Benjamin

  公开号：US20070213506A1

  公开（公告）日：2007-09-13

  Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The methods utilise thiosulfonate or selenenylsulfide compounds as reagents or intermediates. Some proteins and peptides comprising selenenyl-sulfide groups also form part of the invention.

  本发明涉及在蛋白质、肽和氨基酸中形成二硫键的方法和试剂，特别是用于蛋白质、肽和氨基酸的可控糖基化。所述方法利用硫代磺酸盐或硒酰硫酸盐化合物作为试剂或中间体。一些含有硒酰硫酸盐基团的蛋白质和肽也是本发明的一部分。
• Selenophene anti-tumor agents
  申请人：Chang Ching-jer

  公开号：US20070197493A1

  公开（公告）日：2007-08-23

  Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R 1 and R 2 are independently selected from the group consisting of H, CHO, CH 2 OH, and CH 2 NH 2 ; and X and Y are independently selected from the group consisting of Se, S, O, NCH 3 , and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.

  本文介绍了一种作为抗肿瘤剂有用的新型硒杂茂化合物。首选化合物包括式I的化合物：其中R1和R2独立选择自H、CHO、CH2OH和CH2NH2的群；X和Y独立选择自Se、S、O、NCH3和NH的群。本文还描述了含有所述硒杂茂化合物的药物组合物和治疗患有肿瘤的患者的方法。