5-Ethyl-2-isopropyl-4-methyloxazole | 102586-54-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Ethyl-2-isopropyl-4-methyloxazole
• 英文别名: 5-ethyl-4-methyl-2-propan-2-yl-1,3-oxazole
• CAS: 102586-54-9
• 化学式: C₉H₁₅NO
• 分子量: 153.22
• InChiKey: IEYWMNYHQSDLRX-UHFFFAOYSA-N

物化性质

• LogP：
  2.501 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS
  申请人：ASCENTAGE PHARMA (SUZHOU) CO., LTD.

  公开号：US20220396587A1

  公开（公告）日：2022-12-15

  Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a , R 1b , L 1 , L 2 , L 3 , X, A, B and C are as defined as set forth in the specification. Also provided compounds of Formula IA for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.