ZINC;2-ethyl-4-oxopyran-3-olate | 98445-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: ZINC;2-ethyl-4-oxopyran-3-olate
• CAS: 98445-51-3
• 化学式: C₁₄H₁₄O₆Zn
• 分子量: 343.652
• InChiKey: YLCCBOAOVJDSRP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  0.55
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  98.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  zinc(II) sulfate heptahydrate 、 乙基麦芽酚 在 lithium hydroxide monohydrate 作用下， 以 水 为溶剂， 反应 5.5h， 以77%的产率得到ZINC;2-ethyl-4-oxopyran-3-olate
  参考文献：
  名称：

  Investigating the target organs of novel anti-diabetic zinc complexes with organo‑selenium ligands

  摘要：

  Diabetes mellitus (DM) is a serious problem worldwide and is becoming increasingly prevalent. Previously, we reported the use of various zinc (Zn) complexes as new anti-diabetic agents. In this study, we synthesized novel organo-selenium (Se) Zn complexes with hydroxy-pyrone derivatives that have a Zn(Se2O2) coordination mode. The results of in vitro insulin-mimetic analyses showed that the compound bis(3-hydroxy-2-methyl-4(H)-pyran-4- seleno)Zn ([Zn(hmps)(2)]) exhibited the strongest activity among all the complexes. In the in vivo studies of Zn complexes with 3-hydroxy-2-methyl-4(H)-pyran-4-one, maltol, (hmpo) derivatives, [Zn(hmps)(2)] exhibited a stronger anti-diabetic effect than bis(3-hydroxy-2-methyl-4(H)-pyran-4-one)Zn ([Zn(hmpo)(2)]), which had a Zn (O-4) coordination mode. Additionally, we investigated the organ distribution of both Zn and Se by determining the amounts of these elements in the organs of [Zn(hmps)(2)]-administered mice. We then evaluated the effect of treatment with Zn complexes on hepatic lipid accumulation and pancreatic islet hypertrophy by hematoxylin and eosin (HE) histological staining. Zn complexes were found to improve the hypertrophy in the pancreas. There were some reports that Se-contaming Zn complexes such as di(2-selenopyridine-N-oxidato)Zn(II) ([ZPS]) were effective for treating diabetes mellitus, so in this study, we examined different types of zinc complexes with organo-selenium ligands.

  DOI：

  10.1016/j.jinorgbio.2018.05.002