2-(3,4-dimethoxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-dimethoxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.32
• InChiKey: INGGXWWOTDZRPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Compositions and methods of use of derivatized flavanols
  申请人：Kwik-Uribe L. Catherine

  公开号：US20060293259A1

  公开（公告）日：2006-12-28

  The invention relates to compositions containing derivatized flavanols such as methylated flavanols, and methods of use thereof for prophylactic or therapeutic treatment of a human or a veterinary animal for example as anti-platelet agents.

  本发明涉及含有衍生化黄烷醇的组合物，例如甲基化黄烷醇，以及其用于预防或治疗人类或兽医动物的方法，例如作为抗血小板剂的用途。
• COMPOSITIONS AND METHODS OF USE OF DERIVATIZED FLAVANOLS
  申请人：MARS, INCORPORATED

  公开号：EP1898902A2

  公开（公告）日：2008-03-19
• HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies
  申请人：University of Iowa Research Foundation

  公开号：US20180209956A1

  公开（公告）日：2018-07-26

  Disclosed are methods, compositions, kits, and systems for identifying small-molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1-deficient, BRCA2-deficient, and/or PALB2-deficient phenotype by administering the identified small-molecule inhibitors to the subject.
• [EN] COMPOSITIONS AND METHODS OF USE OF DERIVATIZED FLAVANOLS<br/>[FR] COMPOSITIONS ET PROCEDES POUR UTILISER DES FLAVANOLS DERIVES
  申请人：MARS INC

  公开号：WO2007002881A2

  公开（公告）日：2007-01-04

  [EN] The invention relates to compositions containing derivatized flavanols such as methylated flavanols, and methods of use thereof for prophylactic or therapeutic treatment of a human or a veterinary animal for example as anti-platelet agents.
  [FR] La présente invention concerne des compositions contenant des flavanols dérivés tels que des flavanols méthylés, et des procédés pour les utiliser pour le traitement prophylactique ou thérapeutique d'un humain ou d'un animal, par exemple en tant qu'agents anti-plaquettes.
• [EN] HIGH THROUGHPUT SCREENING ASSAY FOR IDENTIFYING INHIBITORS OF RAD52 AND USES OF THE IDENTIFIED INHIBITORS FOR TREATMENT AND/OR PREVENTION OF MALIGNACIES<br/>[FR] ESSAI DE CRIBLAGE À HAUT DÉBIT PERMETTANT D'IDENTIFIER DES INHIBITEURS DE RAD52 ET UTILISATIONS DES INHIBITEURS IDENTIFIÉS POUR LE TRAITEMENT ET/OU LA PRÉVENTION DES MALIGNITÉS
  申请人：UNIV IOWA RES FOUND

  公开号：WO2017015187A1

  公开（公告）日：2017-01-26

  Disclosed are methods, compositions, kits, and systems for identifying small- molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1- deficient, BRCA2 -deficient, and/or PALB2 -deficient phenotype by administering the identified small-molecule inhibitors to the subject.