scopranone A

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: scopranone A
• 英文别名: 2-Ethyl-4-(2-ethylbutyl)-2-hydroxy-5-pent-2-en-3-ylfuran-3-one；2-ethyl-4-(2-ethylbutyl)-2-hydroxy-5-pent-2-en-3-ylfuran-3-one
• 化学式: C₁₇H₂₈O₃
• 分子量: 280.408
• InChiKey: IVLRLNXBYCZYPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-pentanone trisyl hydrazone 在 正丁基锂 、 重水 、 二甲基亚砜 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 氘代二甲亚砜 、 正己烷 、 二氯甲烷 为溶剂， 反应 171.76h， 生成 scopranone A
  参考文献：
  名称：

  Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-11038

  摘要：

  Three new compounds, designated scopranones A-C, were isolated from the culture broth of a soil isolate, Streptomyces sp. BYK-11038, and shown to be inhibitors of bone morphogenetic protein (BMP) induced alkaline phosphatase activity in a BMP receptor mutant cell line. The structures were elucidated using NMR and other spectral data. The scopranones have an unusual structure with two atypical scooplike moieties linked at the tails to form part of a unique 3-furanone ring.

  DOI：

  10.1021/acs.orglett.7b03003

文献信息

• Scopranones with Two Atypical Scooplike Moieties Produced by <i>Streptomyces</i> sp. BYK-11038
  作者：Ryuji Uchida、Daiki Lee、Ibuki Suwa、Masaki Ohtawa、Nozomu Watanabe、Ayumu Demachi、Satoshi Ohte、Takenobu Katagiri、Tohru Nagamitsu、Hiroshi Tomoda

  DOI：10.1021/acs.orglett.7b03003

  日期：2017.11.3

  Three new compounds, designated scopranones A-C, were isolated from the culture broth of a soil isolate, Streptomyces sp. BYK-11038, and shown to be inhibitors of bone morphogenetic protein (BMP) induced alkaline phosphatase activity in a BMP receptor mutant cell line. The structures were elucidated using NMR and other spectral data. The scopranones have an unusual structure with two atypical scooplike moieties linked at the tails to form part of a unique 3-furanone ring.