3-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
• 英文别名: 3-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
• 化学式: C₂₈H₃₂O₁₇
• 分子量: 640.5
• InChiKey: JWCIGPTUZBZFDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  275
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• Composition for prevention or treatment of metabolic syndrome or for antioxidation containing black bean leaf extracts and flavonol glysosides isolated therefrom as active ingredients
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US10765128B2

  公开（公告）日：2020-09-08

  A composition for prevention or treatment of metabolic syndrome or for antioxidation includes black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients. It has been confirmed that the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof effectively inhibit α-glucosidase activity; LDL oxidation and DDP-4; have excellent DPPH radical scavenging activity; inhibitory activity of reactive oxygen species (ROS) accumulation; effectively promote insulin secretion; regulate the expression of major genes; have an excellent ability to reduce a waist/hip circumference ratio; decrease the concentrations of plasma free fatty acid and plasma triglyceride; increase the concentration of plasma HDL-cholesterol; decrease an atherogenic index; increase erythrocyte catalase, SOD and GR activities; decrease erythrocyte lipid peroxide TBARS; decrease the concentrations of inflammatory cytokines MCP-1 and PAI-1, and resistin; and increase the concentration of plasma adiponectin.

  一种用于预防或治疗代谢综合征或抗氧化的组合物包括作为活性成分的黑大豆叶提取物及其分离的黄酮醇苷化合物。经证实，黑豆叶提取物及其分离出的黄酮醇苷化合物能有效抑制α-葡萄糖苷酶活性、低密度脂蛋白氧化和DDP-4；具有极佳的DPPH自由基清除活性；抑制活性氧（ROS）积累；有效促进胰岛素分泌；调节主要基因的表达；具有极佳的降低腰围/臀围比的能力；降低血浆游离脂肪酸和血浆甘油三酯的浓度；提高血浆高密度脂蛋白胆固醇的浓度；降低动脉粥样硬化指数；提高红细胞过氧化氢酶、SOD 和 GR 活性；降低红细胞过氧化脂质 TBARS；降低炎症细胞因子 MCP-1 和 PAI-1 以及抵抗素的浓度；提高血浆脂肪连通素的浓度。
• COMPOSITION FOR PREVENTION OR TREATMENT OF METABOLIC SYNDROME OR FOR ANTIOXIDATION CONTAINING BLACK BEAN LEAF EXTRACTS AND FLAVONOL GLYSOSIDES ISOLATED THEREFROM AS ACTIVE INGREDIENTS
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20190075823A1

  公开（公告）日：2019-03-14

  The present invention relates to a composition for prevention or treatment of metabolic syndrome or for antioxidation comprising black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients. It has been confirmed that the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof in the present invention: effectively inhibit α-glucosidase activity; effectively inhibit LDL oxidation and DDP-4; have excellent DPPH radical scavenging activity; have excellent inhibitory activity of reactive oxygen species (ROS) accumulation; effectively promote insulin secretion in pancreatic beta cells; regulate the expression of major genes for diabetes, obesity, insulin resistance, fatty liver, hyperlipidemia, and atherosclerosis caused by a high-fat diet; have an excellent ability to reduce a waist/hip circumference ratio in adult males and females who are overweight or obese; decrease the concentrations of plasma free fatty acid and plasma triglyceride; increase the concentration of plasma HDL-cholesterol; decrease an atherogenic index; increase erythrocyte catalase, SOD and GR activities; decrease erythrocyte lipid peroxide TBARS; decrease the concentrations of inflammatory cytokines MCP-1 and PAI-1, and resistin which is a hormone secreted in adipocytes; and increase the concentration of plasma adiponectin. Thus, the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof can be usefully used for preventing or treating metabolic syndrome, and also can be usefully used as an antioxidant composition due to the excellent antioxidant activity thereof.