Genetically modified isopropylmalate isomerase enzyme complexes and processes to prepare elongated 2-ketoacids and C5-C10 compounds therewith
申请人:Dow Global Technologies LLC
公开号:US11230705B2
公开(公告)日:2022-01-25
Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
转基因异丙基丙二酸异构酶酶复合物(如LeuCD′酶复合物)、包括转基因异丙基丙二酸异构酶酶复合物(如LeuCD′)在内的微生物、以及用转基因异丙基丙二酸异构酶酶复合物(如LeuCD′)制备C7-C11 2-酮酸的工艺。转基因异丙基丙二酸异构酶复合物(如LeuCD′酶复合物)、微生物和制备C7-C11 2-酮酸的工艺可用于在体内和体外生产C6-C10醛、烷、醇和羧酸。