methyl 3-methyl-4-(4-methylpiperazin-1-ylmethyl)benzoate | 641615-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-methyl-4-(4-methylpiperazin-1-ylmethyl)benzoate
• 英文别名: Methyl 3-methyl-4-[(4-methylpiperazin-1-yl)methyl]benzoate
• CAS: 641615-71-6
• 化学式: C₁₅H₂₂N₂O₂
• 分子量: 262.352
• InChiKey: CDCYVYSYVKMUPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 3-methyl-4-(4-methylpiperazin-1-ylmethyl)phenyl trifluoromethanesulfonate 、 一氧化碳 在 palladium diacetate 1,3-双(二苯基膦)丙烷 作用下， 以 二甲基亚砜 、 1,2-二氯乙烷 为溶剂， 反应 1.0h， 生成 methyl 3-methyl-4-(4-methylpiperazin-1-ylmethyl)benzoate
  参考文献：
  名称：

  AMIDE DERIVATIVE

  摘要：

  公开号：

  EP1533304B1

文献信息

• Amide derivative
  申请人：Asaki Tetsuo

  公开号：US20060014742A1

  公开（公告）日：2006-01-19

  The present invention provides an amide derivative represented by the following general formula (1): wherein R 1 represents a saturated cyclic amino group, R 2 represents alkyl, halogen or haloalkyl, R 3 represents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.
• 1H-1,8-NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS
  申请人：NATCO PHARMA LIMITED

  公开号：US20170114057A1

  公开（公告）日：2017-04-27

  The present invention relates to novel antiproliferative 1H-1,8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.
• 1H-1,8-NAPHTHYRIDIN-2-ONES AS ANTI PROLIFERATIVE COMPOUNDS
  申请人：NATCO PHARMA LIMITED

  公开号：US20170349588A1

  公开（公告）日：2017-12-07

  The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In which the variable groups are as defined herein, and their preparation and use in therapeutic treatment of disorders related to inhibition of tyrosine kinases in warm blooded animals. The compounds can overcome imatinib induced drug resistance.
• US7494997B2
  申请人：——

  公开号：US7494997B2

  公开（公告）日：2009-02-24
• US9765072B2
  申请人：——

  公开号：US9765072B2

  公开（公告）日：2017-09-19