LysoPA(0:0/16:0)

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: LysoPA(0:0/16:0)
• 英文别名: (1-hydroxy-3-phosphonooxypropan-2-yl) hexadecanoate
• 化学式: C₁₉H₃₉O₇P
• 分子量: 410.488
• InChiKey: LPQBQFLKBCPNAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲醇 、 二十六烷酰磷脂酸 在 zooglan 作用下， 反应 48.0h， 生成 LysoPA(0:0/16:0) 、 棕榈酸甲酯 、 2-羟基-3-(膦酰氧基)丙基棕榈酸酯
  参考文献：
  名称：

  Selective phospholipid methanolysis catalyzed by a weakly acidic microbial polysaccharide, zooglan

  摘要：

  Zooglan, a weakly acidic exopolysaccharide produced by Zoogloea ramigera 115, catalyzed the preferential methanolysis of phospatidylcholine compared to other phospholipids when the reaction was carried out in pure methanol at 30 degrees C. The reaction was monitored by thin-layer chromatography (TLC) as well as H-1 and P-31 nuclear magnetic resonance (NMR) spectrometry. Zooglan enhanced the rate of methanolysis of dipalmitoylphosphatidylcholine (DPPC) up to about 170-fold compared to controls such as DPPC alone, pyruvic acid, succinic acid and acetic acid. Furthermore, the methanolysis was different depending on the head groups of the phospholipids. Through this study, we have shown that zooglan can act as an environmentally benign catalytic polysaccharide for methanolysis in pure methanol solution. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.04.008

文献信息

• Selective phospholipid methanolysis catalyzed by a weakly acidic microbial polysaccharide, zooglan
  作者：Sanghoo Lee、Seunho Jung

  DOI：10.1016/j.carres.2008.04.008

  日期：2008.6

  Zooglan, a weakly acidic exopolysaccharide produced by Zoogloea ramigera 115, catalyzed the preferential methanolysis of phospatidylcholine compared to other phospholipids when the reaction was carried out in pure methanol at 30 degrees C. The reaction was monitored by thin-layer chromatography (TLC) as well as H-1 and P-31 nuclear magnetic resonance (NMR) spectrometry. Zooglan enhanced the rate of methanolysis of dipalmitoylphosphatidylcholine (DPPC) up to about 170-fold compared to controls such as DPPC alone, pyruvic acid, succinic acid and acetic acid. Furthermore, the methanolysis was different depending on the head groups of the phospholipids. Through this study, we have shown that zooglan can act as an environmentally benign catalytic polysaccharide for methanolysis in pure methanol solution. (C) 2008 Elsevier Ltd. All rights reserved.