tazobactam | 124995-08-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tazobactam
• 英文别名: 2-methyl-2-triazolylmethylpenam-3-carboxylic acid S,S-dioxide；4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-；3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS: 124995-08-0
• 化学式: C₁₀H₁₂N₄O₅S
• 分子量: 300.295
• InChiKey: LPQZKKCYTLCDGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Lyophilization Process
  申请人：Diago José

  公开号：US20090186865A1

  公开（公告）日：2009-07-23

  An improved process for the production of lyophilized Piperacillin alone or in combination with Tazobactam with improved pH adjustment, by degassing the solution of products to a controlled low carbon dioxide content prior to lyophilization.

  一种改进的方法用于生产冻干哌拉西林单独或与他唑巴坦结合使用，通过在冻干化之前将产品溶液脱气到控制的低二氧化碳含量，以改善pH调节。
• Anhydrous crystal of bata-lactam compound and method for preparation thereof
  申请人：Shimabayashi Akihiro

  公开号：US20090264642A1

  公开（公告）日：2009-10-22

  The present invention provides anhydrous crystals of β-lactam compound represented by the formula: The β-lactam compound of the invention is produced by heating an aqueous solution of a salt of the β-lactam compound and adjusting the pH of the aqueous solution to 3 or lower. The β-lactam compound has excellent storage stability.
• CEPHEM COMPOUNDS, THEIR PRODUCTION AND USE
  申请人：NAEJA-RGM PHARMACEUTICALS INC.

  公开号：US20170166587A1

  公开（公告）日：2017-06-15

  Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain.
• US7674898B2
  申请人：——

  公开号：US7674898B2

  公开（公告）日：2010-03-09
• US9751894B2
  申请人：——

  公开号：US9751894B2

  公开（公告）日：2017-09-05