2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-(2-hydroxyethoxy)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-(2-hydroxyethoxy)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside
• 英文别名: 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one
• 化学式: C₂₉H₃₄O₁₇
• 分子量: 654.6
• InChiKey: MBHXKZDTQCSVPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  275
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• [EN] PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS<br/>[FR] PYRAZOLO[4,3-D]PYRIMIDINES UTILES EN TANT QU'INHIBITEURS DE KINASES
  申请人：ORIGENIS GMBH

  公开号：WO2012143144A1

  公开（公告）日：2012-10-26

  The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

  本发明涉及一种能够抑制一个或多个激酶，特别是SYK（脾酪氨酸激酶）、LRRK2（富含亮氨酸重复的激酶2）和/或MYLK（肌球蛋白轻链激酶）或其突变体的化合物的新颖化合物（I）的公式。这些化合物在治疗各种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和与激素相关的疾病。
• [EN] HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE KINASES
  申请人：ORIGENIS GMBH

  公开号：WO2012143143A1

  公开（公告）日：2012-10-26

  The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

  本发明涉及一种能够抑制一个或多个激酶，特别是SYK（脾酪氨酸激酶）、LRRK2（富含亮氨酸重复激酶2）和/或MYLK（肌球蛋白轻链激酶）或其突变体的化合物的新颖化合物（I）的公式。这些化合物在治疗各种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和与激素相关的疾病。
• Low-emulsifier or emulsifier-free systems of the oil-in-water type with a content of stabilizers and an amino-substituted hydroxybenzophenone
  申请人：——

  公开号：US20030124158A1

  公开（公告）日：2003-07-03

  Cosmetic or dermatological preparations which represent finely disperse systems of the oil-in-water type, comprising a) an oil phase, b) a water phase, c) one or more stabilizers, d) at most 2.00% by weight of one or more emulsifiers, and e) an amino-substituted hydroxybenzophenone of the formula I 1

  化妆品或皮肤科制剂，代表油包水型的细分散系统，包括 a) 油相， b) 水相， c) 一种或多种稳定剂， d) 最多占总重量的2.00%的一种或多种乳化剂，以及 e) 公式I的氨基取代羟基苯酮 1
• Preparation having antioxidant properties
  申请人：Merck Patent GmbH

  公开号：US20040067894A1

  公开（公告）日：2004-04-08

  The invention relates to a preparation having antioxidant properties, comprising at least one compound of the formula I 1 where R 1 to R 10 may be identical or different and are selected from H, OR 11 , straight-chain or branched C 1 - to C 20 -alkyl groups, straight-chain or branched C 3 - to C 20 -alkenyl groups, straight-chain or branched C 1 - to C 20 -hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C 3 - to C 10 -cycloalkyl groups and/or C 3 - to C 12 -cycloalkenyl groups, where the rings may each also be bridged by —(CH 2 ) n — groups, where n=1 to 3, where all OR 11 are, independently of one another, OH, C 1 - to C 20 -alkoxy groups, C 3 - to C 20 -alkenyloxy groups, straight-chain or branched C 1 - to C 20 -hydroxyalkoxy groups and/or C 3 - to C 10 -cycloalkoxy groups and/or C 3 - to C 12 -cycloalkenyloxy groups, where the rings may each also be bridged by —(CH 2 ) n — groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, with the proviso that at least 3 radicals from R 1 to R 7 are OH and that at least 2 pairs of adjacent —OH groups are present in the molecule, or R 2 , R 5 and R 6 are OH and the radicals R 1 , R 3 , R 4 and R 7-10 are H.

  该发明涉及一种具有抗氧化性能的制剂，包括至少一种具有以下式I1的化合物，其中R1到R10可能相同也可能不同，选择自H、OR11、直链或支链的C1到C20烷基基团、直链或支链的C3到C20烯基基团、直链或支链的C1到C20羟基烷基基团，其中羟基可能连接到链的一级或二级碳原子上，此外，烷基链也可能被氧原子中断，和/或C3到C10环烷基基团和/或C3到C12环烯基基团，其中环可能也通过—(CH2)n—基团相互连接，其中n=1到3，其中所有的OR11都是独立的，OH、C1到C20烷氧基团、C3到C20烯氧基团、直链或支链的C1到C20羟基烷氧基团和/或C3到C10环烷氧基团和/或C3到C12环烯氧基团，其中环可能也通过—(CH2)n—基团相互连接，其中n=1到3，和/或单糖和/或寡糖基团，但至少3个从R1到R7的基团是OH，并且分子中至少有2对相邻的—OH基团，或者R2、R5和R6是OH，基团R1、R3、R4和R7-10是H。
• Light-protection agents
  申请人：Merck Patent GmbH

  公开号：US20040091433A1

  公开（公告）日：2004-05-13

  The invention relates to a preparation having light-protection properties comprising at least one compound of the formula I 1 where R 1 and R are selected from H and OR 11 , where each OR 11 , independently of the others, is OH, a straight-chain or branched C 1 - to C 20 alkoxy group, a straight-chain or branched C 3 - to C 20 -alkenyloxy group, a straight-chain or branched C 1 - to C 20 -hydroxyalkoxy group, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or a C 3 - to C 10 -cycloalkoxy group and/or C 3 - to C 12 -cyclo-alkenyloxy group, where the rings may each also be bridged by —(CH 2 ) n — groups, where n=1 to 3, and/or a mono- and/or oligoglycosyl radical, with the proviso that at least one radical from R 1 and R 2 is OR 11 , and R 3 is a radical OR 11 , and R 4 to R 7 and R 10 may be identical or different and are, independently of one another, radicals which are substantially inert with respect to the UV properties.

  本发明涉及一种具有光保护性能的制剂，包括至少一种式I1的化合物，其中R1和R从H和OR11中选择，其中每个OR11独立于其他OR11，是OH、直链或支链C1-C20烷氧基、直链或支链C3-C20烯氧基、直链或支链C1-C20羟基烷氧基，其中羟基可以与链中的一级或二级碳原子结合，此外，烷基链也可以被氧断裂，和/或C3-C10环烷氧基和/或C3-C12环烯氧基，其中环也可以被—(CH2)n—基桥接，其中n=1至3，和/或单糖和/或寡糖基团，但至少来自R1和R2中的一个基团是OR11，R3是OR11基团，R4至R7和R10可以相同或不同，并且独立于彼此，是与紫外线性质相对惰性的基团。