Arogenic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arogenic acid
• 英文别名: 1-(2-amino-2-carboxyethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid
• 化学式: C₁₀H₁₃NO₅
• 分子量: 227.21
• InChiKey: MIEILDYWGANZNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 羧苄西林 、 异丙基-beta-D-硫代半乳糖吡喃糖苷 、 三羟甲基氨基甲烷盐酸盐 、 乙二胺四乙酸 、 1,4-dithio-D,L-threitol 、 苄脒盐酸盐 、 6-氨基己酸 反应 16.67h， 以pET21-TyrA-AT obtained in example 3的产率得到Arogenic acid
  参考文献：
  名称：

  Novel targets for herbicides and transgenic plants resistant to said herbicides

  摘要：

  本发明涉及一种新型酶，具有芳香氨基酸酰基转移酶活性，特别是植物的芳香氨基酸酰基转移酶酶和编码该酶的基因。本发明的芳香氨基酸酰基转移酶酶催化酪氨酸生物合成代谢途径的最后阶段，并且作为潜在的除草剂靶标。因此，本发明还涉及一种用于识别靶向该酶的除草剂化合物的方法，该除草剂化合物通过与该酶固定来防止酪氨酸生物合成。本发明还涉及对靶向酪氨酸生物合成途径中涉及的酶，特别是涉及L-酪氨酸预苯酸转化的酶，特别是芳香氨基酸酰基转移酶酶的除草剂化合物具有耐药性的转基因植物。这些植物通过在其组织中表达预苯酸脱氢酶酶而变得耐药，该酶对该除草剂化合物不敏感，并使植物能够在接受该除草剂化合物处理时合成酪氨酸。

  公开号：

  US20040117872A1

文献信息

• SYNTHESIS OF ISOTOPICALLY-LABELED FUNCTIONALIZED DIENES
  申请人：Martinez Rodolfo A.

  公开号：US20100317886A1

  公开（公告）日：2010-12-16

  All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.

  所有标记的碳最终都来源于CO，因为碳-13是通过将一氧化碳（CO）进行低温分馏而与其较轻的同位素分离的。 制备用于起始材料的立体特异性和位点特异性化合物将满足对标记化合物的不断增长需求，包括同位素标记的官能化二烯烃。 官能化二烯烃化合物可用作生产同位素标记的药物、生物分子和天然产物的前体。
• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。
• Hair Loss Prevention by Natural Amino Acid and Peptide Complexes
  申请人：GUPTA SHYAM K

  公开号：US20090253668A1

  公开（公告）日：2009-10-08

  This invention relates to certain skin and hair care agents of formula (I), derived from natural amino acids and peptides. These agents provide multi-functional treatment of enzyme-related skin, hair and scalp problems, for example, hair aging including premature hair loss and hair graying; male pattern baldness; hair loss from dandruff; alopecia; split ends, acne, darkened skin, dark circles around eyes, stretch marks, wrinkles and fine lines, loss of collagen, loss of skin pliability and combinations thereof:

  本发明涉及公式（I）的某些皮肤和头发护理剂，这些护理剂源自天然氨基酸和肽。这些护理剂提供多功能的酶相关皮肤、头发和头皮问题的治疗，例如，头发老化，包括过早脱发和白发；男性型脱发；头皮屑引起的脱发；脱发斑秃；分叉，痤疮，皮肤变黑，眼周黑眼圈，妊娠纹，皱纹和细纹，胶原蛋白流失，皮肤柔韧性流失和它们的组合：
• Methods for identifying herbicidal compounds
  申请人：Bayer CropScience S.A.

  公开号：US07279302B2

  公开（公告）日：2007-10-09

  The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.

  本发明涉及一种新型酶，具有芳香氨基酸酰基转移酶活性，特别是植物的芳香氨基酸酰基转移酶酶和编码该酶的基因。本发明的芳香氨基酸酰基转移酶酶催化酪氨酸生物合成代谢途径的最后阶段，因此是除草剂的潜在靶点。因此，本发明还涉及一种用于识别靶向该酶的除草剂化合物的方法，所述除草剂化合物通过固定在该酶上防止酪氨酸生物合成。本发明还涉及对靶向酪氨酸生物合成途径中的酶的除草剂化合物具有耐受性的转基因植物，特别是参与L-酪氨酸预苯酸转化的酶，特别是芳香氨基酸酰基转移酶酶。所述植物通过在其组织中表达一种预苯酸酰基转移酶酶而变得耐药，该酶对所述除草剂化合物不敏感并使植物能够合成酪氨酸，尽管被处理了所述除草剂化合物。
• Topical Delivery System for Antiaging and Skin Whitening Agents
  申请人：GUPTA SHYAM K.

  公开号：US20090074691A1

  公开（公告）日：2009-03-19

  This invention relates to certain hydroxyaryl alkanols, alkyl amines, alkyl amino acids, alkyl amino esters, and alkyl amino alkanols (“Hydroxyaryl compounds”) of formula (I). A method of topical application of said hydroxyaryl compounds is also disclosed. The treatment of certain enzyme dysfunctions that cause skin or hair condition such as darkened skin including age spots, dark circles around the eyes, and discoloration of skin from stretch marks; skin conditions related to acne including excess facial oil and facial pore size; premature hair aging including hair loss and graying; inflammation including intra-cellular and extra-cellular inflammation; skin aging including wrinkles and fine lines; loss of collagen including thinning skin and loss of skin pliability; malfunction of tyrosinase group of enzymes; and malfunction of matrix metalloprotease group of enzymes with said hydroxyaryl compounds is also disclosed:

  本发明涉及公式（I）的某些羟基芳基丙醇、烷基胺、烷基氨基酸、烷基氨基酯和烷基氨基丙醇（“羟基芳基化合物”）。还公开了一种使用上述羟基芳基化合物的局部应用方法。本发明还公开了使用上述羟基芳基化合物治疗某些酶功能障碍，这些酶功能障碍导致皮肤或头发状况的异常，例如黑化的皮肤，包括老年斑、眼周黑眼圈和妊娠纹引起的皮肤色素沉着；与痤疮相关的皮肤状况，包括过多的面部油脂和面部毛孔大小；过早的头发老化，包括脱发和白发；炎症，包括细胞内和细胞外炎症；皮肤衰老，包括皱纹和细纹；胶原蛋白流失，包括皮肤变薄和失去弹性；酪氨酸酶类酶的功能障碍；以及基质金属蛋白酶类酶的功能障碍。