4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
• 化学式: C₃₃H₅₇N₃O₉
• 分子量: 639.8
• InChiKey: MIZMDSVSLSIMSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Formulations comprising cyclic compounds
  申请人：Botti, Paolo

  公开号：EP1905454A1

  公开（公告）日：2008-04-02

  This invention relates to the use of a cyclic compound of formula (I) wherein A, B independently in each occurrence is alkane-i,j-diyl having k carbon atoms, i and independently j being less than or equal k and k being selected from 1 to 10, wherein said alkane-i,j-diyl (i) may comprise one or more double bonds; (ii) is optionally substituted; and/or (iii) comprises a cycle, wherein the total number of cycles being cyclic sugars in said compound is selected from 0 to 4 and is less than p-(n+m); X,Y independently in each occurrence is a biocompatible functional group comprising at least one oxygen atom or two sulphur atoms; n, m independently of each other are selected from 0 to 20; p is selected from 1 to 10; n+m is equal or greater than 1; and p-(n+m) is selected from 3 to 30; wherein said compound is capable of forming a complex with a protonated primary and/or protonated secondary amino group and/or a protonated guanidinium group for the manufacture of a pharmaceutical or diagnostic composition further comprising a pharmaceutically or diagnostically active agent, said active agent comprising one or more protonated primary and/or protonated secondary amino groups and/or a protonated guanidinium groups, wherein (a) transmembrane and/or transmucosal delivery; (b) solubility in non-aqueous solvents; and/or (c) stability of said active agent are improved.

  本发明涉及使用公式（I）的环状化合物，其中A，B分别在每次出现时为具有k个碳原子的烷基-i，j-二基，i和j分别独立于k，k选择从1到10，其中所述烷基-i，j-二基（i）可以包括一个或多个双键；（ii）可选地被取代；和/或（iii）包括一个环，其中所述化合物中的环状糖的总数选择从0到4，并且小于p-（n+m）；X，Y分别在每次出现时是至少包含一个氧原子或两个硫原子的生物相容性功能基团；n，m彼此独立地选择从0到20；p选择从1到10；n+m等于1或更大；p-（n+m）选择从3到30；其中所述化合物能够与质子化的一级和/或质子化的二级氨基基团和/或质子化的鸟氨酸基团形成复合物，用于制造制药或诊断组合物，进一步包括药物学或诊断学活性剂，所述活性剂包括一个或多个质子化的一级和/或质子化的二级氨基基团和/或质子化的鸟氨酸基团，其中（a）跨膜和/或经黏膜递送；（b）在非水溶剂中的溶解度；和/或（c）所述活性剂的稳定性得到改善。
• Endoparasitizide Mittel die Praziquantel und Epsiprantel enthalten
  申请人：BAYER AG

  公开号：EP0662326A2

  公开（公告）日：1995-07-12

  Die vorliegende Erfindung betrifft die Verwendung von Praziquantel und Epsiprantel zur Steigerung der endoparasitiziden Wirkung von cyclischen Depsipeptiden in endoparasitiziden Mitteln.

  本发明涉及使用吡喹酮和依匹喹酮来增强环去肽类杀内寄生虫剂的杀内寄生虫活性。
• Milchsäure-haltige cyclische Depsipeptide mit 18 Ringatomen als endoparasitizide Mittel und Verfahren zu ihrer Herstellung
  申请人：BAYER AG

  公开号：EP0669343A1

  公开（公告）日：1995-08-30

  Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung Milchsäurehaltiger optisch aktiver, cyclischer Depsipeptide mit 18 Ringatomen mit Hilfe von Pilzstämmen der Art Fusarium oder daraus isolierten enzymatischen Präparationen.

  本发明涉及一种借助镰刀菌属真菌菌株或从中分离出的酶制剂生产光学活性环状去肽类化合物的工艺，这种环状去肽类化合物含有 18 个环原子的乳酸。
• Current detection type ion selective electrode
  申请人：KYOTO DAIICHI KAGAKU CO., LTD.

  公开号：EP0683390A1

  公开（公告）日：1995-11-22

  A current detection type ion selective electrode having a working electrode which has an ion selective part at one end of a hollow insulating body (1) having open ends and a lead wire (12) which is inserted in an interior of said hollow insulating body through the other end of the hollow insulating body and electrically contacted to the ion sensitive part (3) and functions as means for picking up a signal from the ion selective part, in which the ion sensitive part has a paste-form electrode made of a paste of electrically conductive particles containing an ionophore and a solvent therein, and a current detection type dry ion selective electrode having an electrode system including a measuring electrode and a counter electrode which are formed on an insulating substrate (5), in which the measuring electrode is the above paste-form electrode (13). Such electrode can be produced at a low cost and has a small impedance.

  一种电流检测型离子选择电极，其工作电极的离子选择部分位于两端开口的空心绝缘体（1）的一端，导线（12）通过空心绝缘体的另一端插入所述空心绝缘体的内部，并与离子敏感部分（3）电接触，作为从离子选择部分拾取信号的装置、一种电流检测型干式离子选择电极，其电极系统包括在绝缘基板（5）上形成的测量电极和对电极，其中测量电极为上述糊状电极（13）。这种电极的生产成本低廉，阻抗小。
• Method for measuring ion concentration
  申请人：KYOTO DAIICHI KAGAKU CO., LTD.

  公开号：EP0833149A1

  公开（公告）日：1998-04-01

  A method for measuring a concentration of ions contained in a sample liquid using a current-detection ion-selective electrode includes the steps of contacting the current-detection ion-selective electrode and a counter electrode to the sample liquid; and applying at least one potential which is lower than a minimum value of a limiting current potential range for the ions between the current-detection ion-selective electrode and the counter electrode.

  使用电流检测离子选择电极测量样品液体中所含离子浓度的方法包括以下步骤：将电流检测离子选择电极和对电极与样品液体接触；在电流检测离子选择电极和对电极之间施加至少一个电位，该电位低于离子的极限电流电位范围的最小值。