DL-N(Me2)Tyr(Me)-DL-OxiIle-DL-Val-DL-N(Me)Tyr-DL-N(Me)Tyr-OMe

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: DL-N(Me2)Tyr(Me)-DL-OxiIle-DL-Val-DL-N(Me)Tyr-DL-N(Me)Tyr-OMe
• 英文别名: [1-[[1-[[3-(4-hydroxyphenyl)-1-[[3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]-methylamino]-1-oxopropan-2-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl] 2-(dimethylamino)-3-(4-methoxyphenyl)propanoate
• 化学式: C₄₄H₆₀N₄O₁₀
• 分子量: 805.0
• InChiKey: MOVAFFRTIYGUBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  58
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  175
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• [EN] APRATYRAMIDE THERAPEUTIC AGENTS AND METHODS OF TREATMENT<br/>[FR] AGENTS THÉRAPEUTIQUES À BASE D'APRATYRAMIDE ET PROCÉDÉS DE TRAITEMENT
  申请人：UNIV FLORIDA

  公开号：WO2019104200A1

  公开（公告）日：2019-05-31

  The invention is directed towards Apratyramide linear depsipeptide compounds, pharmaceutical compositions thereof, and methods of affecting wound healing, and methods of affecting the biological processes involved in wound healing (e.g., inflammation, cell proliferation, tissue granulation, remodeling of scar tissue, etc.).

  该发明涉及Apratyramide线性脱氨肽化合物，其制药组合物，以及影响伤口愈合的方法，以及影响涉及伤口愈合的生物过程的方法（例如炎症、细胞增殖、组织肉芽生长、瘢痕组织重塑等）。
• Apratyramide therapeutic agents and methods of treatment
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US11358989B2

  公开（公告）日：2022-06-14

  The invention is directed towards Apratyramide linear depsipeptide compounds, pharmaceutical compositions thereof, and methods of affecting wound healing, and methods of affecting the biological processes involved in wound healing (e.g., inflammation, cell proliferation, tissue granulation, remodeling of scar tissue, etc.).

  本发明涉及杏酰胺线性去肽化合物、其药物组合物、影响伤口愈合的方法，以及影响伤口愈合所涉及的生物过程（如炎症、细胞增殖、组织肉芽形成、疤痕组织重塑等）的方法。
• APRATYRAMIDE THERAPEUTIC AGENTS AND METHODS OF TREATMENT
  申请人：University of Florida Research Foundation, Incorporated

  公开号：US20200361995A1

  公开（公告）日：2020-11-19

  The invention is directed towards Apratyramide linear depsipeptide compounds, pharmaceutical compositions thereof, and methods of affecting wound healing, and methods of affecting the biological processes involved in wound healing (e.g., inflammation, cell proliferation, tissue granulation, remodeling of scar tissue, etc.).