5-hydroxy-11-propyl-12-oxa-16,17-dithia-2,20-diazabicyclo[12.4.2]icosane-3,13,19-trione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 5-hydroxy-11-propyl-12-oxa-16,17-dithia-2,20-diazabicyclo[12.4.2]icosane-3,13,19-trione
• 化学式: C₁₈H₃₀N₂O₅S₂
• 分子量: 418.6
• InChiKey: MVEXFNFRQDFJIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  155
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• DIPEPTIDE DERIVATIVE FOR THE TREATMENT OF CANCER
  申请人：Deshmukh Sunil Kumar Jaiwant Rao

  公开号：US20130130992A1

  公开（公告）日：2013-05-23

  This invention relates to purified compound of formula (1). The invention includes all isomeric forms and all tautomeric forms of the compound of formula (1) and pharmaceutically acceptable salts thereof. The present invention further relates to processes for the production of the compound of formula (1) by fermentation of the fungal strain of sterile mycelium (PM0509732/MTCC5544) and to pharmaceutical compositions containing the compound as active ingredient and its use in medicines for treatment of cancer.
• [EN] DI PEPTIDE DERIVATIVE FOR THE TREATMENT OF CANCER<br/>[FR] DIPEPTIDE DÉRIVÉ POUR LE TRAITEMENT DU CANCER
  申请人：PIRAMAL LIFE SCIENCES LTD

  公开号：WO2012020364A1

  公开（公告）日：2012-02-16

  This invention relates to purified compound of formula (1). The invention includes all isomeric forms and all tautomeric forms of the compound of formula (1) and pharmaceutically acceptable salts thereof. The present invention further relates to processes for the production of the compound of formula (1) by fermentation of the fungal strain of sterile mycelium (PM0509732/MTCC5544) and to pharmaceutical compositions containing the compound as active ingredient and its use in medicines for treatment of cancer.