24-Hydroxy-tetracosansaeuremethylester | 37477-30-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 24-Hydroxy-tetracosansaeuremethylester
• 英文别名: Methyl 24-hydroxytetracosanoate
• CAS: 37477-30-8
• 化学式: C₂₅H₅₀O₃
• 分子量: 398.67
• InChiKey: NCWSJQBNRVEQAI-UHFFFAOYSA-N

物化性质

• 熔点：
  63.2-63.4 °C
• 沸点：
  485.0±18.0 °C(Predicted)
• 密度：
  0.901±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  28
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  24-Hydroxy-tetracosansaeuremethylester 在 迭氮酸 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

  摘要：

  C. Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.047
• 作为产物：
  描述：

  甲醇 、 24-(tetrahydro-2H-pyran-2-yloxy)tetracosanoic acid 在 氯化亚砜 作用下， 以90%的产率得到24-Hydroxy-tetracosansaeuremethylester
  参考文献：
  名称：

  Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

  摘要：

  C. Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.047

文献信息

• ABRAMS S. R., CHEM. AND PHYS. LIPIDS, 1981, 28, NO 4, 379-384
  作者：ABRAMS S. R.

  DOI：——

  日期：——
• Method For Producing an Aqueous Polymer Dispersion
  申请人：Kong Xiang-Ming

  公开号：US20080199925A1

  公开（公告）日：2008-08-21

  A process for preparing an aqueous polymer dispersion, in which, in an aqueous medium, in a first reaction stage, a hydroxycarboxylic acid compound is reacted in the presence of an enzyme and of a dispersant, and also, if appropriate, of a low water solubility organic solvent and/or of an ethylenically unsaturated monomer, to give a polyester, and thereafter, in the presence of the polyester, in a second reaction stage, an ethylenically unsaturated monomer is free-radically polymerized.