(R)-6-oxopiperidine-1,2-dicarboxylic acid | 72002-30-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-6-oxopiperidine-1,2-dicarboxylic acid
• 英文别名: (2R)-6-oxopiperidine-1,2-dicarboxylic acid
• CAS: 72002-30-3
• 化学式: C₇H₉NO₅
• 分子量: 187.152
• InChiKey: SIZQUUKDCWFTAT-SCSAIBSYSA-N

物化性质

• 沸点：
  437.0±38.0 °C(Predicted)
• 密度：
  1.286±0.06 g/cm3(Predicted)
• 溶解度：
  DMF: 30 mg/ml,DMSO: 30 mg/ml,乙醇: 30 mg/ml,PBS (pH 7.2): 10 mg/ml

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933790090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  (R)-6-oxopiperidine-1,2-dicarboxylic acid 在 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 64.5h， 生成 methyl (2R,6S)-6-(3,4,5-trifluorophenyl)piperidine-2-carboxylate
  参考文献：
  名称：

  TWO CYCLIC OXOMORPHORIN DERIVATIVES

  摘要：

  本发明涉及一种由式(I)表示的化合物：其中R1代表C1-3烷基基团，R2代表氢原子或C1-3烷基基团，Ar代表苯基或类似物，可能被1至3个取代基取代，X代表氧原子或类似物，n和m是0至2的整数，或其药学上可接受的盐，以及其作为药物的用途。

  公开号：

  US20080207900A1

文献信息

• BICYCLIC OXOMORPHOLINE DERIVATIVE
  申请人：Kimura Teiji

  公开号：US20100113773A1

  公开（公告）日：2010-05-06

  The present invention relates to a compound represented by formula (I): wherein R 1 represents a C1-3 alkyl group, R 2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

  本发明涉及一种由以下化学式（I）表示的化合物：其中，R1代表C1-3烷基；R2代表氢原子或C1-3烷基；Ar代表苯基或类似物，可以被1至3个取代基取代；X代表氧原子或类似物；n和m相同或不同，是0至2的整数；或其药学上可接受的盐，并将其用作药物。
• Bicyclic oxomorpholine derivative
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US08008293B2

  公开（公告）日：2011-08-30

  The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

  本发明涉及一种化合物，其化学式表示为(I)：其中R1代表C1-3烷基，R2代表氢原子或C1-3烷基，Ar代表苯基或类似物，可以被1至3个取代基取代，X代表氧原子或类似物，n和m相同或不同，都是0至2的整数，或其药学上可接受的盐，并将其用作药物。
• MORPHOLINE TYPE CINNAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1953154A1

  公开（公告）日：2008-08-06

  The present invention relates to a compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, and R4 are the same or different and each represent a hydrogen atom or a C1-6 alkyl group; X1 represents a C1-6 alkylene group that may be substituted; Xa represents a methoxy group or a fluorine atom; Xb represents an oxygen atom or a methylene group, provided that Xb is only an oxygen atom when Xa is a methoxy group; and Ar1 represents an aryl group, pyridinyl group, aryloxy group, or pyridinyloxy group that may have a substituent such as a halogen atom; and to use of the compound or salt as a pharmaceutical agent.

  本发明涉及一种由式 (I) 代表的化合物： 或其药理上可接受的盐，其中 R1、R2、R3 和 R4 相同或不同，且各自代表氢原子或 C1-6 烷基；X1 代表可被取代的 C1-6 亚烷基；Xa 代表甲氧基或氟原子；Xb代表氧原子或亚甲基，但当Xa为甲氧基时，Xb仅为氧原子；Ar1代表芳基、吡啶基、芳氧基或吡啶氧基，可具有卤素原子等取代基；以及将化合物或盐用作药剂。
• BICYCLIC CINNAMIDE COMPOUND
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1953158A1

  公开（公告）日：2008-08-06

  A bicyclic cinnamide compound represented by the general formula (I): wherein ---- represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group optionally substituted by one to three substituents; R1 and R2 each represents a C1-6 alkyl group, a hydroxyl group, etc.; Z1 represents an optionally substituted methylene group or vinylene group, an oxygen atom, or an imino group optionally substituted by a Cl-6 alkyl group or a Cl-6 acyl group; and p, q, and r each is an integer of 0 to 2. It functions to reduce Aβ40 and Aβ42. It is hence useful especially as a prevention or remedy for neurodegenerative diseases of which Aβ is causative, such as Alzheimer's disease and Down's syndrome.

  由通式(I)代表的双环肉桂化合物： 其中 ---- 代表单键或双键；Ar1 代表任选被一至三个取代基取代的苯基或吡啶基；R1 和 R2 分别代表 C1-6 烷基、羟基等；Z1 代表任选被取代的亚甲基或亚乙烯基、氧原子或任选被 Cl-6 烷基或 Cl-6 丙烯酸基取代的亚氨基；p、q 和 r 分别为 0 至 2 的整数。 它具有降低 Aβ40 和 Aβ42 的功能。因此，它特别适用于预防或治疗 Aβ 导致的神经退行性疾病，如阿尔茨海默氏症和唐氏综合症。
• TWO CYCLIC OXOMORPHORIN DERIVATIVES
  申请人：KIMURA Teiji

  公开号：US20080207900A1

  公开（公告）日：2008-08-28

  The present invention relates to a compound represented by formula (I): wherein R 1 represents a C1-3 alkyl group, R 2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.

  本发明涉及一种由式(I)表示的化合物：其中R1代表C1-3烷基基团，R2代表氢原子或C1-3烷基基团，Ar代表苯基或类似物，可能被1至3个取代基取代，X代表氧原子或类似物，n和m是0至2的整数，或其药学上可接受的盐，以及其作为药物的用途。