Serratamolid | 5285-25-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Serratamolid
• 英文别名: 7,14-Diheptyl-3,10-bis(hydroxymethyl)-1,8-dioxa-4,11-diazacyclotetradecane-2,5,9,12-tetrone
• CAS: 5285-25-6
• 化学式: C₂₆H₄₆N₂O₈
• 分子量: 514.66
• InChiKey: NMEMNUVHBNAERZ-UHFFFAOYSA-N

物化性质

• 熔点：
  159-160 °C
• 沸点：
  817.1±65.0 °C(Predicted)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• USE OF CYCLIC DEPSIPEPTIDE AS A CHEMOTHERAPEUTIC AGENT AGAINST CANCER
  申请人：Universidad de Barcelona

  公开号：EP1553080A1

  公开（公告）日：2005-07-13

  Serratamolide, also named cyclo[(3R)-3-hydroxydecanoyl-L-seryl-(3R)-3-hydroxydecanoyl-L-seryl], is a cyclic depsipeptide isolated from cultures of bacteria of the species Serratia marcescens. Serratamolide decreases the viability of, and induces apoptosis in several cancer cells (leukemias, myelomas, carcinomas, etc.), virtually with no effect on non-cancer cells. This makes serratamolide, and its pharmaceutically acceptable addition salts and/or solvates, useful as anticancer chemotherapeutic agent, particularly against leukemia, lymphoma, myeloma, carcinoma, melanoma and sarcoma.

  Serratamolide 又名环[(3R)-3-羟基癸酰基-L-丝氨酰-(3R)-3-羟基癸酰基-L-丝氨酰]，是从 Serratia marcescens 菌种的培养物中分离出来的一种环状去肽。沙拉他莫利内酯可降低多种癌细胞（白血病、骨髓瘤、癌等）的活力并诱导其凋亡，但对非癌细胞几乎没有影响。因此，丝裂莫来及其药学上可接受的加成盐和/或溶解物可用作抗癌化疗剂，特别是针对白血病、淋巴瘤、骨髓瘤、癌、黑色素瘤和肉瘤。
• Cyclic depsipeptide as chemotherapeutic anticancer agent
  申请人：Tomas Perez Ricardo

  公开号：US20050239694A1

  公开（公告）日：2005-10-27

  Serratamolide, also named cyclo[(3R)-3-hydroxydecanoyl-L-seryl-(3R)-3-hydroxydecanoyl-L-seryl], is a cyclic depsipeptide isolated from cultures of bacteria of the species Serratia marcescens . Serratamolide decreases the viability of, and induces apoptosis in several cancer cells (leukemias, myelomas, carcinomas, etc.), virtually with no effect on non-cancer cells. This makes serratamolide, and its pharmaceutically acceptable addition salts and/or solvates, useful as anticancer chemotherapeutic agent, particularly against leukemia, lymphoma, myeloma, carcinoma, melanoma and sarcoma.

  塞拉他莫内酯，又名环[(3R)-3-羟基癸酰基-L-丝氨酰-(3R)-3-羟基癸酰基-L-丝氨酰]，是一种环状去肽类化合物，从以下物种的细菌培养物中分离出来 Serratia marcescens .沙拉他莫利内酯可降低多种癌细胞（白血病、骨髓瘤、癌等）的活力并诱导其凋亡，但对非癌细胞几乎没有影响。这使得丝裂莫来及其药学上可接受的加成盐和/或溶解物可用作抗癌化疗剂，特别是针对白血病、淋巴瘤、骨髓瘤、癌、黑色素瘤和肉瘤。
• [EN] USE OF CYCLIC DEPSIPEPTIDE AS A CHEMOTHERAPEUTIC AGENT AGAINST CANCER<br/>[ES] DEPSIPÉPTIDO CÍCLICO COMO AGENTE QUIMIOTERAPÉUTICO CONTRA EL CÁNCER<br/>[FR] DEPSIPEPTIDE CYCLIQUE UTILISE COMME AGENT CHIMIOTHERAPEUTIQUE CONTRE LE CANCER
  申请人：UNIV BARCELONA

  公开号：WO2004031130A1

  公开（公告）日：2004-04-15

  La serratamolida, también llamada ciclo [(3R)-3-hidroxidecanoil-L-seril-(3R)-3-hidroxidecanoil-L-serilo], es un depsipéptido cíclico aislado de cultivos de bacterias de la especie Serratia marcescens. La serratamolida disminuye la viabilidad de varias células cancerosas (leucemias, mielomas, carcinomas, etc.) e induce la apoptosis en las mismas, prácticamente sin efecto en células no cancerosas. Esto hace que la serratamolida, y sus sales de adición y/o solvatos farmacéuticamente aceptables, sean útiles como agente quimioterapéutico anticanceroso, particularmente frente a leucemia, linfoma, mieloma, carcinoma, melanoma y sarcoma.