1,2,3,4,5-penta-O-acetyl-D-xylitol | 74033-71-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2,3,4,5-penta-O-acetyl-D-xylitol
• 英文别名: 1,2,3,4,5-penta-o-acetyl-xylitol；DL-Arabitol-pentaacetat；Arabino-pentaacetat；Xylitol-pentaacetat；Arabinitol-pentaacetat；1,2,3,4,5-Penta-O-acetylpentitol；2,3,4,5-tetraacetyloxypentyl acetate
• CAS: 74033-71-9
• 化学式: C₁₅H₂₂O₁₀
• 分子量: 362.334
• InChiKey: NVKPIAUSOPISJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  25
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  132
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  rel(2R,3r,4S)-3-acetoxy-1,2:4,5-diepoxypentane 、 乙酸酐 、 四丁基醋酸铵 生成 1,2,3,4,5-penta-O-acetyl-D-xylitol
  参考文献：
  名称：

  HOLLAND, D.;STODDART, J. F., CARBOHYDR. RES., 1982, 100, 207-220

  摘要：

  DOI：

文献信息

• Methods and materials for reducing amyloid beta levels within a mammal
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US10639322B2

  公开（公告）日：2020-05-05

  This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.

  本文提供了降低哺乳动物（如患有阿尔茨海默病的哺乳动物）体内淀粉样β水平的方法和材料。例如，本文提供了使用含有马铃薯多糖制剂的组合物减轻阿尔茨海默病的一种或多种症状的方法。在某些情况下，本文提供的含有马铃薯多糖制剂的组合物可用于增加中枢神经系统衍生的淀粉样β多肽的结合、螯合和/或降解，从而抑制神经纤维斑的形成。
• Methods and materials for treating diabetes or liver steatosis
  申请人：The Research Foundation for The State University of New York

  公开号：US11160825B2

  公开（公告）日：2021-11-02

  This document provides methods and materials for treating diabetes and/or liver steatosis. For example, methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of diabetes or liver steatosis are provided. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to treat fatty liver disease.

  本文提供了治疗糖尿病和/或肝脏脂肪变性的方法和材料。例如，提供了使用含有马铃薯多糖制剂的组合物减轻糖尿病或肝脏脂肪变性的一种或多种症状的方法。在某些情况下，本文提供的含有马铃薯多糖制剂的组合物可用于治疗脂肪肝。
• METHODS AND MATERIALS RELATED TO NUTRITIONAL SUPPLEMENT COMPOSITIONS CONTAINING A POTATO POLYSACCHARIDE PREPARATION
  申请人：The Research Foundation for The State University of New York

  公开号：EP2834255B1

  公开（公告）日：2020-11-04
• METHODS AND MATERIALS FOR REDUCING AMYLOID BETA LEVELS WITHIN A MAMMAL
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20180078575A1

  公开（公告）日：2018-03-22

  This document provides methods and materials for reducing amyloid beta levels within a mammal (e.g. a mammal having Alzheimer's disease). For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce one or more symptoms of Alzheimer's disease. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to increase binding, sequestration, and/or degradation of CNS-derived amyloid beta polypeptides, thereby inhibiting the formation of neurofibrillary plaques.
• METHODS AND MATERIALS FOR TREATING CANCER
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US20180078599A1

  公开（公告）日：2018-03-22

  This document provides methods and materials for treating cancer. For example, this document provides methods for using compositions containing a potato polysaccharide preparation to reduce the number of cancer cells in a mammal. In some cases, a composition containing a potato polysaccharide preparation provided herein can be used to reduce the number of cancer cells in a mammal, wherein the cancer cells express a KRAS polypeptide.