7-(4,7-Dihydroxyoct-2-enoyloxy)-4-hydroxyoct-2-enoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 7-(4,7-Dihydroxyoct-2-enoyloxy)-4-hydroxyoct-2-enoic acid
• 英文别名: 7-(4,7-dihydroxyoct-2-enoyloxy)-4-hydroxyoct-2-enoic acid
• 化学式: C₁₆H₂₆O₇
• 分子量: 330.378
• InChiKey: ORRRSPCMMIBQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  ficiolide A 在 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 、 7-(4,7-Dihydroxyoct-2-enoyloxy)-4-hydroxyoct-2-enoic acid
  参考文献：
  名称：

  Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus

  摘要：

  Regarding targeted disruption of epigenetic regulators, histone methyltransferase and deacetylase in a plant endophytic fungus Pestalotiopsis fici have been uncovered as an unexplored chemical repertoire. Manipulation of epigenetic regulators led to the isolation of 15 new polyketides, including pestaloficiols T-W (1-3 and 5), as well as 11 macrodiolide ficiolides A-K (6-16). Ficiolide K (16) was found to contain a very rare 1,6-anhydro-pyranose moiety. Finally, the biosynthetic origin of macrodiolide was characterized by isotope-labeling experiments.

  DOI：

  10.1021/acs.orglett.6b00562

文献信息

• Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus
  作者：Guangwei Wu、Haichuan Zhou、Peng Zhang、Xiuna Wang、Wei Li、Weiwei Zhang、Xingzhong Liu、Hong-Wei Liu、Nancy P. Keller、Zhiqiang An、Wen-Bing Yin

  DOI：10.1021/acs.orglett.6b00562

  日期：2016.4.15

  Regarding targeted disruption of epigenetic regulators, histone methyltransferase and deacetylase in a plant endophytic fungus Pestalotiopsis fici have been uncovered as an unexplored chemical repertoire. Manipulation of epigenetic regulators led to the isolation of 15 new polyketides, including pestaloficiols T-W (1-3 and 5), as well as 11 macrodiolide ficiolides A-K (6-16). Ficiolide K (16) was found to contain a very rare 1,6-anhydro-pyranose moiety. Finally, the biosynthetic origin of macrodiolide was characterized by isotope-labeling experiments.