2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | 681028-87-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• 英文别名: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
• CAS: 681028-87-5
• 化学式: C₂₁H₂₀O₁₂
• mdl: MFCD00808406
• 分子量: 464.4
• InChiKey: OVSQVDMCBVZWGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  207
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• 4-methylcatechol Derivatives and Uses Thereof
  申请人：THANARES GMBH

  公开号：US20160347782A1

  公开（公告）日：2016-12-01

  The invention relates to phenoxy derivatives with glycosidically bound sugar moieties, pharmaceutical compositions containing such compounds, uses of such compounds and compositions, and methods of making such compounds and pharmaceutical compositions.

  这项发明涉及具有糖苷键结合的苯氧基衍生物，包含这些化合物的药物组合物，这些化合物和组合物的用途，以及制备这些化合物和药物组合物的方法。
• NOVEL POLYPHENOL GLYCOSIDE DERIVED FROM ACEROLA
  申请人：Nichirei Biosciences Inc.

  公开号：EP1840131A1

  公开（公告）日：2007-10-03

  It is an objective of the present invention to provide a polyphenol glycoside isolated from acerola, which has a binding mode that has not been conventionally known, and to provide the use of the same. The present invention relates to a compound represented by formula (I): and an antioxidant, a glucosidase inhibitor, a food, a cosmetic, and a skin preparation for external use, each of which comprises such compound.

  本发明的目的是提供一种从针叶樱桃中分离出来的多酚苷，它具有传统上未知的结合模式，并提供其用途。 本发明涉及一种由式（I）表示的化合物： 以及一种抗氧化剂、一种葡萄糖苷酶抑制剂、一种食品、一种化妆品和一种外用皮肤制剂，其中每一种都包含这种化合物。
• Reduction of in vitro genotoxicity of pollen extracts by removal of flavonoids
  申请人：STALLERGENES

  公开号：US11027010B2

  公开（公告）日：2021-06-08

  The invention relates to grass pollen extracts containing reduced amount of flavonoid glycosides in order to minimize the risks of genotoxicity of the grass pollen extracts. The invention also relates to a method of preparing grass pollen extracts containing reduced amount of flavonoid glycosides by ultrafiltration. Flavonoid glycosides are naturally present in grass pollen extracts and they have been identified as being responsible for the formation of flavonoid aglycones, which are genotoxic in vitro, under the influence of enzymes contained in the grass pollen extracts.

  本发明涉及含有少量黄酮苷的草花粉提取物，目的是将草花粉提取物的遗传毒性风险降至最低。本发明还涉及一种通过超滤制备含有较少量黄酮苷的草花粉提取物的方法。黄酮苷天然存在于草花粉提取物中，它们已被确认是在草花粉提取物所含酶的影响下形成黄酮苷醛酸的原因，而黄酮苷醛酸在体外具有遗传毒性。
• Anti-inflammatory cranberry flavonol extract preparations
  申请人：Vorsa Nicholi

  公开号：US20060088610A1

  公开（公告）日：2006-04-27

  The present invention is directed to extracts of cranberries ( Vaccinium macrocarpon ) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-β-xylopyranoside, quercetin-3-β-glucoside, quercetin-3-α-arabinopyranoside, 3′-methoxyquercetin-3-α-xylopyranoside, quercetin-3-O-(6″-p-coumaroyl)-β-galactoside, and quercetin-3-O-(6″-benzoyl)-β-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-α-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.

  本发明涉及蔓越莓（Vaccinium macrocarpon）的提取物。 蔓越莓 )的提取物，该提取物包含基本不含花青素和原花青素的混合黄酮醇或纯化的蔓越莓黄酮醇化合物，包括杨梅素-3-β-木吡喃糖苷槲皮素-3-β-葡萄糖苷、槲皮素-3-α-阿拉伯吡喃糖苷、3′-甲氧基槲皮素-3-α-木吡喃糖苷、槲皮素-3-O-(6″-对香豆酰基)-β-半乳糖苷和槲皮素-3-O-(6″-苯甲酰基)-β-半乳糖苷。本发明还包括使用这些提取物以及包含蔓越莓黄酮醇化合物槲皮素-3-α-阿拉伯呋喃糖苷的提取物来治疗炎症性疾病。此外，还叙述了利用本发明提取物或化合物的药物、食品、膳食补充剂和化妆品组合物。
• PHARMAZEUTISCHE ZUSAMMENSETZUNG MIT EINEM TRIHYDROXYCHROMENONE-DERIVAT
  申请人：Analyticon Discovery GmbH

  公开号：EP2164477A1

  公开（公告）日：2010-03-24