Flavandiol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Flavandiol
• 英文别名: 2-phenyl-3,4-dihydrochromene-2,3-diol
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.27
• InChiKey: PBZMVAYHJDFHIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM<br/>[FR] DERIVES PYRIDINE SERVANT A INHIBER LE SYSTEME D'ECHANGE SODIUM/CALCIUM
  申请人：ORION CORP

  公开号：WO2004063191A1

  公开（公告）日：2004-07-29

  Therapeutically active compounds of formula (I) or (II) wherein X is -O-, -CH2- or -C(O)-; Z is -CHR12- or a valence bond; Y is -CH2-, -C(O)-, CH(OR13)-, -O-, -S-; provided that in case Z is a valence bond, Y is not C(O); the dashed line representing an optional double bond in which case Z is -CR12- ­and Y is -CH2-, -C(O)- or -CH(OR10)- (in formula II) or -CH- (in formula I); R2 and R3 are independently H, lower alkyl, lower alkoxy, -NO2, halogen, -CF3, -OH, benzyloxy or a group of formula (IIIa). R1 is H, CN, halogen, -CONH2, -COOR15, CH2NR15R18, NHC(O)R5, NHCH2R5, NHR20, NR21R22, NHC(NH)NHCH3 or, in case the compound is of formula (II) wherein the optional double bond exists or in case R2 or R3 is benzyloxy or a group of formula (IIIa) or in case the pyridine ring of formula (I) or (II) is attached to the oxygen atom in 3-, 4- or 5-position, R1 can also be -NO2 or NR16R17; R4 is H, -NO2, CN, halogen, -CONH2, -COOR15, -CH2NR15R18, -NR16R17, NHC(O)R5 or -NHC(NH)NHCH3; R5 is alkyl substituted with 1-3 substituents selected from the group consisting of halogen, amino and hydroxy, or carboxyalkyl, in which the alkyl portion is optionally substituted with 1-3 substituents selected from the group consisting of halogen, amino and hydroxyl, -CHR6NR,R8 or one of the following groups: formula (IVa), (IVb), (IVc), (IVd), (IVe), and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na+/Ca2+ exchange mechanism.

  式（I）或（II）的治疗活性化合物，其中X为-O-，-CH2-或-C（O）-；Z为-CHR12-或一个价键；Y为- -，-C（O）-，CH（OR13）-，-O-，-S-；条件是如果Z为一个价键，则Y不是C（O）；虚线表示可选的双键，此时Z为-CR12-，Y为- -，-C（O）-或-CH（OR10）-（在式（II）中）或-CH-（在式（I）中）；R2和R3独立地为H，较低的烷基，较低的烷氧基，-NO2，卤素，-CF3，-OH，苄氧基或式（IIIa）的基团。R1为H，CN，卤素，-CONH2，-COOR15， NR15R18，NHC（O）R5，NH R5，NHR20，NR21R22，NHC（NH）NHCH3的基团，或者，如果化合物为式（II），其中存在可选的双键，或者如果R2或R3为苄氧基或式（IIIa）的基团，或者如果式（I）或（II）的吡啶环附着在3-，4-或5-位置的氧原子上，则R1也可以是- 或NR16R17；R4为H，- ，CN，卤素，-CONH2，-COOR15，- NR15R18，-NR16R17，NHC（O）R5或-NHC（NH）NHCH3；R5为烷基，其上取代有1-3个取自卤素、氨基和羟基或羧基的取代基，其中烷基部分可选地取代有1-3个取自卤素、氨基和羟基的取代基，-CHR6NR,R8或以下所示的一个基团之一：式（IVa），（IVb），（IVc），（IVd），（IVe），以及其药用可接受的盐和酯。这些化合物是Na+/Ca2+交换机制的有效抑制剂。
• Pyridine derivatives useful for inhibiting sodium/calcium exchange system
  申请人：Otsomaa Leena

  公开号：US20060241147A1

  公开（公告）日：2006-10-26

  Therapeutically active compounds of formula (I) or (II): wherein the variables in formulas (I) and (II) are defined in the description, and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of Na + /Ca 2+ exchange mechanism.

  公式（I）或（II）的治疗活性化合物： 其中公式（I）和（II）中的变量在说明中定义，并且其药学上可接受的盐和酯。这些化合物是钠/钙交换机制的有效抑制剂。
• FOOD IMPROVING BLOOD FLOW
  申请人：Toyo Shinyaku Co., Ltd.

  公开号：EP1547591A1

  公开（公告）日：2005-06-29

  The composition of the present invention contains proanthocyanidins as active components. When the composition further comprises ascorbic acid or a derivative thereof, the fluidity of blood and effect of protecting blood vessels are further improved. This composition may be a food composition or pharmaceutical composition for improving the blood fluidity. Particularly, this composition is useful as a beverage.

  本发明的组合物含有原花青素作为活性成分。当该组合物进一步包含抗坏血酸或其衍生物时，血液的流动性和保护血管的效果会得到进一步改善。这种组合物可以是改善血液流动性的食品组合物或药物组合物。特别是，本组合物可用作饮料。
• PROCESS FOR PRODUCING PROANTHOCYANIN-RICH MATERIAL
  申请人：Toyo Shinyaku Co., Ltd.

  公开号：EP1602653A1

  公开（公告）日：2005-12-07

  The method of the present invention, comprises the process of treating an extract or squeezed juice of a plant with a salt and/or an alkaloid and then with a synthetic resin adsorbent, or the process of treating an extract or squeezed juice of a plant with a synthetic resin adsorbent and then with a salt and/or an alkaloid. By this method, a proanthocyanidin-containing product containing highly bioactive OPCs at a high ratio can be obtained easily and efficiently.

  本发明的方法包括先用盐和/或生物碱处理植物提取物或榨汁，再用合成树脂吸附剂处理，或先用合成树脂吸附剂处理植物提取物或榨汁，再用盐和/或生物碱处理。 通过这种方法，可以轻松高效地获得含有高比例高生物活性 OPC 的原花青素产品。
• PROCESS FOR PRODUCING PRODUCT CONTAINING PROANTHOCYANIDIN IN HIGH PROPORTION
  申请人：Toyo Shinyaku Co., Ltd.

  公开号：EP1669338A1

  公开（公告）日：2006-06-14

  A proanthocyanidin-containing product containing a large amount of highly bioactive OPCs can be obtained easily by treating an extract or juice of a plant with at least two types of adsorbents that differ from one another in at least one of material, pore radius, specific surface area, and an ability of adsorbing and releasing a substance based on the molecular weight of the substance.

  用至少两种吸附剂处理植物的提取物或果汁，就能轻松获得含有大量高生物活性 OPC 的原花青素产品，这两种吸附剂至少在材料、孔半径、比表面积以及基于物质分子量的吸附和释放能力等方面存在差异。