2-Methoxy-5,7,3',4'-tetrahydroxyflavan | 87367-19-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-Methoxy-5,7,3',4'-tetrahydroxyflavan
• 英文别名: 2-(3,4-dihydroxyphenyl)-3-methoxy-3,4-dihydro-2H-chromene-5,7-diol
• CAS: 87367-19-9
• 化学式: C₁₆H₁₆O₆
• 分子量: 304.29
• InChiKey: PDHSAQOQVUXZGQ-UHFFFAOYSA-N

物化性质

• 熔点：
  >156°C (dec.)
• 溶解度：
  可溶于丙酮（轻微，超声处理）、DMSO（轻微）、甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2932999099

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• [EN] POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY<br/>[FR] CONJUGUÉS POLYPHÉNOL-PEPTIDE POUR L'ADMINISTRATION CIBLANT LE NOYAU
  申请人：UNIV WIEN

  公开号：WO2020136240A1

  公开（公告）日：2020-07-02

  The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and Met; (ii) at least one polyphenol which is covalently bound to the peptide; and (iii) optionally at least one cargo which, if present, is covalently bound to the peptide. The polyphenol-peptide conjugate can be encapsulated with silica. The invention thus also provides silica particles comprising the polyphenol-peptide conjugate encapsulated by a silica shell. The silica particles allow the efficient cellular uptake and targeted delivery of the polyphenol-peptide conjugate into the cell nucleus, and can therefore advantageously be used for nuclear-targeted gene or drug delivery.

  本发明涉及一种由以下组成的多酚-肽共轭物：（i）包括氨基酸序列Arg-Arg-X1-Leu的肽，其中X1是从lie、Leu、Val、Phe、Trp和Met中独立选择的一个或两个疏水性氨基酸；（ii）至少一种共价结合到肽上的多酚；以及（iii）可选地，至少一种共价结合到肽上的载荷。多酚-肽共轭物可以被硅化物封装。因此，本发明还提供了由硅壳封装的多酚-肽共轭物的硅颗粒。硅颗粒能够有效地被细胞摄取并定向传递到细胞核中，因此可以有利地用于核靶向基因或药物传递。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Compositions and methods of use of derivatized flavanols
  申请人：Kwik-Uribe L. Catherine

  公开号：US20060293259A1

  公开（公告）日：2006-12-28

  The invention relates to compositions containing derivatized flavanols such as methylated flavanols, and methods of use thereof for prophylactic or therapeutic treatment of a human or a veterinary animal for example as anti-platelet agents.

  本发明涉及含有衍生化黄烷醇的组合物，例如甲基化黄烷醇，以及其用于预防或治疗人类或兽医动物的方法，例如作为抗血小板剂的用途。
• Treatment of COPD using a histidine decarboxylase inhibitor sole or combined with an anti-H1 drug or with a leucotriene receptor antagonist
  申请人：Nicolaou, Mike

  公开号：EP2559434A2

  公开（公告）日：2013-02-20

  The invention provides a method for the treatment of COPD and/or gastrointestinal disease conditions ameliorated by histamine management in a subject, comprising administering to the subject an effective amount of a histidine decarboxylase inhibitor.

  本发明提供了一种治疗慢性阻塞性肺病和/或通过组胺管理改善受试者胃肠道疾病状况的方法，包括向受试者施用有效量的组氨酸脱羧酶抑制剂。