5-Hydroxy-2-(4-hydroxyphenyl)-7-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one | 81992-85-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-Hydroxy-2-(4-hydroxyphenyl)-7-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one
• CAS: 81992-85-0
• 化学式: C₃₃H₄₀O₁₉
• 分子量: 740.7
• InChiKey: PEFASEPMJYRQBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  52
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  304
• 氢给体数：
  11
• 氢受体数：
  19

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• Herbal formulation for the treatment of piles
  申请人：Palpu Pushpangadan

  公开号：US20060141065A1

  公开（公告）日：2006-06-29

  The present invention provides a novel herbal formulation for use in treatment of piles. Formulation(s) comprises of leaves of Moringa oliefera , tender leaves of Pongaemia pinnata , whole plant of Cassia occidentalis and leaves of Albizia lebbeck . The formulation can be used as an emulsion or as a soft gelatin capsule for oral dosage forms or in the form of ointment. Moringa olifera used as carminative, stomachic and abortifacient. Pongaemia pinnata is useful in treatment of diseases like dairrhoea, flatulence and for cleaning ulcer and sores. Cassia occidentalis is used for treatment of hysteria, dysentery and other stomach problem. Albizia lebbeck is used in inflammation, itching, leucoderma and also used for strengthening of gums.

  本发明提供了一种新型草药配方，用于治疗痔疮。该配方包括辣木叶、红木嫩叶、金合欢全草和合欢叶。该配方可以作为乳状液或软胶囊剂型口服，或作为软膏使用。辣木叶用作驱风、开胃和引产剂。红木嫩叶对治疗腹泻、肠胃气胀以及清洗溃疡和疮疖有益。金合欢全草用于治疗癔病、痢疾和其他肠胃问题。合欢叶用于消炎、止痒、白癜风，并用于牙龈强化。
• Pharmaceutical composition containing substance inhibiting HSP47 production
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP0742012A2

  公开（公告）日：1996-11-13

  A pharmaceutical composition comprising a substance inhibiting HSP47 production, selected from the group consisting of a malt extract, a flavonoid compound, a protein-bound-polysaccharide obtained from a fungus belonging to Coriolus versicolor, a paeoniflorin derivative, a tocopherol derivative, and a ferulic acid derivative, and a pharmaceutically acceptable carrier is disclosed. The substance inhibiting HSP47 production can efficiently improve physiological conditions of a patient suffering from diseases exhibiting pathosis of overproduction of the extracellular matrix, and efficiently treat such diseases. Further, the substance is useful for preventing or treating various diseases accompanied with abnormal growth of the vascularization.

  本发明公开了一种药物组合物，该组合物包含一种抑制 HSP47 生成的物质，该物质选自麦芽提取物、黄酮类化合物、从属于 Coriolus versicolor 的真菌中获得的蛋白结合多糖、芍药苷衍生物、生育酚衍生物和阿魏酸衍生物组成的组，以及一种药学上可接受的载体。这种抑制 HSP47 生成的物质可以有效改善患有细胞外基质过度生成病症的患者的生理状况，并有效治疗此类疾病。此外，该物质还可用于预防或治疗伴有血管异常生长的各种疾病。
• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。
• COMPOSITION FOR PROTECTING ORGAN, TISSUE OR CELL AND UTILIZATION THEREOF
  申请人：MG Pharmacy Inc.

  公开号：EP1535514A1

  公开（公告）日：2005-06-01

  The present invention provides a composition for efficiently protecting and preserving organs, tissues or cells. In particular, the present invention provides a protective composition which can be used during operations. Specifically, the present invention provides a composition for protecting and preserving organs, tissues or cells, comprising a polyphenol. A method is also provided for protecting an organ, tissue or cell in a subject, comprising 1) exposing the organ, tissue or cell to a polyphenol. Such a composition and a polyphenol is effective in protecting a function of an organ (particularly, the heart, brain, nerve, spinal cord and the like).

  本发明提供了一种有效保护和保存器官、组织或细胞的组合物。特别是，本发明提供了一种可在手术过程中使用的保护性组合物。具体来说，本发明提供了一种用于保护和保存器官、组织或细胞的组合物，其中包含一种多酚。本发明还提供了一种用于保护受试者器官、组织或细胞的方法，包括 1) 将器官、组织或细胞暴露于多酚。这种组合物和多酚可有效保护器官（特别是心脏、大脑、神经、脊髓等）的功能。