2-Heptyl-4,5-dimethylthiazole | 87262-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Heptyl-4,5-dimethylthiazole
• 英文别名: 2-heptyl-4,5-dimethyl-1,3-thiazole
• CAS: 87262-50-8
• 化学式: C₁₂H₂₁NS
• 分子量: 211.37
• InChiKey: PSZGSWWQPRJONL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
  申请人：Incyte Corporation

  公开号：US10695337B2

  公开（公告）日：2020-06-30

  The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了哌啶-4-基氮杂环丁烷衍生物及其组合物和使用方法，这些衍生物可调节Janus激酶1（JAK1）的活性，并可用于治疗与JAK1活性有关的疾病，例如包括炎症性疾病、自身免疫性疾病、癌症和其他疾病。
• PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS
  申请人：Incyte Corporation

  公开号：US20170246157A1

  公开（公告）日：2017-08-31

  The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
• US9999619B2
  申请人：——

  公开号：US9999619B2

  公开（公告）日：2018-06-19