1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2,3-dihydroxypropan-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2,4-Dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2,3-dihydroxypropan-1-one
• 英文别名: 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(3,4-dihydroxyphenyl)-2,3-dihydroxypropan-1-one
• 化学式: C₁₆H₁₆O₈
• 分子量: 336.29
• InChiKey: PWZYYCLVFFWJDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  148
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• [EN] NOVEL ANTI-INFLAMMATORY DIHYDROCHALCONE DERIVATIVES AND USE THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE DIHYDROCHALCONE ANTI-INFLAMMATOIRES ET LEUR UTILISATION
  申请人：ISRAEL STATE

  公开号：WO2013001490A1

  公开（公告）日：2013-01-03

  Disclosed are dihydrochaicone derivatives useful in the treatment of inflammatory and neuro-inflammatory diseases such as Alzheimer and Parkinson or conditions such as stroke. Both a and β carbons of the dihydrochaicone are hydroxylated. Also disclosed are methods of using such compounds in the treatment of inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.