(S)-3-azido-1-(4-methoxyphenyl)propan-1-ol | 1036715-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-3-azido-1-(4-methoxyphenyl)propan-1-ol
• 英文别名: (1S)-3-azido-1-(4-methoxyphenyl)propan-1-ol
• CAS: 1036715-74-8
• 化学式: C₁₀H₁₃N₃O₂
• 分子量: 207.232
• InChiKey: CIPZBKNKOWBSIZ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酸异丙烯酯 、 (RS)-3-azido-1-(4-methoxyphenyl)propan-1-ol 在 Pseudomonas cepacia lipase immobilized on diatomaceous earth 作用下， 以 异丙醚 为溶剂， 反应 42.0h， 以46%的产率得到(R)-3-azido-1-(4-methoxyphenyl)propyl acetate
  参考文献：
  名称：

  Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed transesterification

  摘要：

  An enantioselective synthesis of chiral gamma-azidoalcohols via lipase-catalyzed resolution is described. The efficiency of various lipases and the effect of different solvents have been studied. Pseudomonas cepacia immobilized on diatomaceous earth (PS-D) in n-hexane catalyzed the transesterification process in an efficient manner providing gamma-azidoalcohols in high enantiomeric excess. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.028

文献信息

• Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed transesterification
  作者：Ahmed Kamal、M. Shaheer Malik、Ahmad Ali Shaik、Shaik Azeeza

  DOI：10.1016/j.tetasy.2008.03.028

  日期：2008.5

  An enantioselective synthesis of chiral gamma-azidoalcohols via lipase-catalyzed resolution is described. The efficiency of various lipases and the effect of different solvents have been studied. Pseudomonas cepacia immobilized on diatomaceous earth (PS-D) in n-hexane catalyzed the transesterification process in an efficient manner providing gamma-azidoalcohols in high enantiomeric excess. (C) 2008 Elsevier Ltd. All rights reserved.