6-azaniumyl-2-[(3-azaniumyl-3-carboxylatopropanoyl)amino]hexanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 6-azaniumyl-2-[(3-azaniumyl-3-carboxylatopropanoyl)amino]hexanoate
• 化学式: C10H19N3O5
• 分子量: 261.28
• InChiKey: QGNYWQOMJSTUQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  165
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY
  申请人：Hansen Carl L.

  公开号：US20110306522A1

  公开（公告）日：2011-12-15

  The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.

  微流控结构的使用使得蛋白质结晶的高通量筛选成为可能。在一种实施方式中，集成的组合混合芯片允许精确计量试剂，以快速创建大量可能的结晶条件，并在芯片上观察到可能的晶体形成。在另一种实施方式中，微流控结构可以用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有前途的条件，并允许随后集中尝试获得晶体生长。
• HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS
  申请人：California Institute of Technology

  公开号：US20140041727A1

  公开（公告）日：2014-02-13

  High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

  通过将目标材料的溶液同时引入微型流体装置的多个腔室中，实现对目标材料结晶的高通量筛选。然后，操纵微型流体装置来改变腔室中的溶液条件，从而同时提供大量的结晶环境。改变溶液条件的控制可以采用各种技术，包括但不限于通过体积排斥将结晶剂体积计量到腔室中，通过微型加工结构的尺寸确定结晶剂体积的困扰，或通过交叉正交流道定义的连接点阵列中的样品和结晶剂的交叉通道注入。
• High throughput screening of crystallization materials
  申请人：California Institute of Technology, A California Corporation

  公开号：US20030061687A1

  公开（公告）日：2003-04-03

  High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

  目标材料结晶的高通量筛选是通过将目标材料溶液同时引入微型流体设备的多个腔室来实现的。然后操纵微型流体设备来改变腔室中的溶液条件，从而同时提供大量的结晶环境。对变化的溶液条件的控制可采用多种技术，包括但不限于通过体积排阻将结晶剂计量到腔室中，根据微制造结构的尺寸决定结晶剂的体积，或将样品和结晶剂跨通道注入由相交的正交流道定义的结点阵列中。
• Microfluidic protein crystallography
  申请人：California Institute of Technology

  公开号：US20040115731A1

  公开（公告）日：2004-06-17

  The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.

  使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施方案中，集成组合混合芯片可精确计量试剂，快速创造大量潜在的结晶条件，并在芯片上观察可能的晶体形成。在另一个实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件，并允许随后进行重点尝试，以获得晶体生长。
• Crystal growth devices and systems, and methods for using same
  申请人：Nassef Ramez Hany

  公开号：US20050019794A1

  公开（公告）日：2005-01-27

  High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

  目标材料结晶的高通量筛选是通过将目标材料溶液同时引入微型流体设备的多个腔室来实现的。然后操纵微型流体设备来改变腔室中的溶液条件，从而同时提供大量的结晶环境。对变化的溶液条件的控制可采用多种技术，包括但不限于通过体积排阻将结晶剂计量到腔室中，根据微制造结构的尺寸决定结晶剂的体积，或将样品和结晶剂跨通道注入由相交的正交流道定义的结点阵列中。