[1-[2-(4-Hydroxyphenyl)ethoxy]-1-oxopropan-2-yl] 2-hydroxypropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: [1-[2-(4-Hydroxyphenyl)ethoxy]-1-oxopropan-2-yl] 2-hydroxypropanoate
• 英文别名: [1-[2-(4-hydroxyphenyl)ethoxy]-1-oxopropan-2-yl] 2-hydroxypropanoate
• 化学式: C₁₄H₁₈O₆
• 分子量: 282.29
• InChiKey: QQZBDXHGXQUEBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• POLYMERIC BIOMATERIALS DERIVED FROM MONOMERS COMPRISING HYDROXYACIDS AND PHENOL COMPOUNDS AND THEIR MEDICAL USES
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US20150045451A1

  公开（公告）日：2015-02-12

  The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

  本发明提供了一种新的酚类化合物类别，这些化合物由羟基酸和酪醇或酪醇类似物衍生而来，可用作制备生物相容性聚合物的单体，并且由这些单体羟基酸酚化合物制备的生物相容性聚合物，包括新型可生物降解和/或可生物吸收的聚合物。这些具有增强生物吸收性和加工性的生物相容性聚合物或聚合物组合物在各种医疗应用中非常有用，例如在医疗器械和控释治疗制剂中。本发明还提供了制备这些单体羟基酸酚化合物和生物相容性聚合物的方法。