1-<3-(diethoxyphosphorylmethoxy)pyrrolidin-1-yl>uracil | 145061-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-<3-(diethoxyphosphorylmethoxy)pyrrolidin-1-yl>uracil
• 英文别名: 1-[3-(Diethoxyphosphorylmethoxy)pyrrolidin-1-yl]pyrimidine-2,4-dione
• CAS: 145061-81-0
• 化学式: C₁₃H₂₂N₃O₆P
• 分子量: 347.308
• InChiKey: BEBPRGWGJWEQSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  97.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-<3-(diethoxyphosphorylmethoxy)pyrrolidin-1-yl>uracil 在 吡啶 、 1H-1,2,4-三唑 、 三甲基溴硅烷 、 氨 、 4-氯苯基二氯磷酸酯 作用下， 以 二氯甲烷 为溶剂， 反应 46.33h， 生成 1-<3-(phosphonomethoxy)pyrrolidin-1-yl>cytosine
  参考文献：
  名称：

  Synthesis of [3-(phosphonomethoxy)pyrrolidin-1-yl] derivatives of pyrimidines and purines: analogues of 2′,3′-dideoxynucleotides

  摘要：

  Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2',3'-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.

  DOI：

  10.1039/p19920002259
• 作为产物：
  描述：

  1,4-dibromo-2-chloromethoxybutane 在 吡啶 、 硫酸 、 一水合肼 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 43.08h， 生成 1-<3-(diethoxyphosphorylmethoxy)pyrrolidin-1-yl>uracil
  参考文献：
  名称：

  Synthesis of [3-(phosphonomethoxy)pyrrolidin-1-yl] derivatives of pyrimidines and purines: analogues of 2′,3′-dideoxynucleotides

  摘要：

  Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2',3'-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.

  DOI：

  10.1039/p19920002259

文献信息

• Synthesis of [3-(phosphonomethoxy)pyrrolidin-1-yl] derivatives of pyrimidines and purines: analogues of 2′,3′-dideoxynucleotides
  作者：Michael R. Harnden、Richard L. Jarvest、Martin J. Parratt

  DOI：10.1039/p19920002259

  日期：——

  Pyrrolidin-1-yl derivatives of pyrimidines and purines, incorporating the phosphonomethoxy group as a phosphate mimic, were prepared as analogues of 2',3'-dideoxynucleotides. The heterocyclic bases uracil, thymine, cytosine, adenine and hypoxanthine were constructed upon the primary amino group of the N-aminopyrrolidine 7, which was prepared by reaction of the dibromide 6 with hydrazine.