7-[3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,6-dihydroxychromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-[3,4-Dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,6-dihydroxychromen-4-one
• 化学式: C₂₀H₁₈O₁₁
• 分子量: 434.3
• InChiKey: QWGPBCPIKAIUCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• [EN] COMPOSITIONS OF FLAVONOIDS AND FLAVONOID-CONTAINING EXTRACTS AND THE TREATMENT OF DISEASES<br/>[FR] COMPOSITIONS DE FLAVONOIDES ET D'EXTRAITS QUI CONTIENNENT DES FLAVONOIDES, ET TRAITEMENT DE MALADIES
  申请人：SHANGHAI COMMAN PHARMACEUTICAL

  公开号：WO2005020881A2

  公开（公告）日：2005-03-10

  In this invention we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula (I). Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fish, Oroxylum indicum (L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.