5,5-dimethyl-1-cyclopentene-1-carboxylic acid | 154222-75-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5,5-dimethyl-1-cyclopentene-1-carboxylic acid
• 英文别名: 5,5-Dimethylcyclopent-1-ene-1-carboxylic acid；5,5-dimethylcyclopentene-1-carboxylic acid
• CAS: 154222-75-0
• 化学式: C₈H₁₂O₂
• mdl: MFCD19231111
• 分子量: 140.182
• InChiKey: USPSEEUGTLAWOE-UHFFFAOYSA-N

物化性质

• 沸点：
  228.3±19.0 °C(Predicted)
• 密度：
  1.072±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,5-dimethyl-1-cyclopentene-1-carboxylic acid 在 氯化亚砜 作用下， 反应 1.0h， 以81%的产率得到(9ci)-5,5-二甲基-1-环戊烯-1-羰酰氯
  参考文献：
  名称：

  Photocyclization of Enamides. 38. Reductive Photocyclization of a-(Methylthio)- and a-(Arylthio)enamides

  摘要：

  Reductive photocyclization of alpha-(methylthio)enamide (2) gave exclusively six-membered lactams (3) and (4) while the same reaction of alpha-(arylthio)enamides (6) and (12) was found to afford-five-membered lactams (7) and (13) as major products. A novel total synthesis of (+/-)-polyzonimine (18b) was accomplished by applying the newly found reductive photocyclization of alpha-(naphthylthio)enamide leading to the formation of five-membered lactams.

  DOI：

  10.3987/com-93-6465
• 作为产物：
  描述：

  2,2-二甲基环戊酮 在 吡啶 、 氢氧化钾 、 zinc(II) iodide 、 三氯氧磷 作用下， 以 二乙二醇 、 苯 为溶剂， 反应 109.5h， 生成 5,5-dimethyl-1-cyclopentene-1-carboxylic acid
  参考文献：
  名称：

  Photocyclization of Enamides. 38. Reductive Photocyclization of a-(Methylthio)- and a-(Arylthio)enamides

  摘要：

  Reductive photocyclization of alpha-(methylthio)enamide (2) gave exclusively six-membered lactams (3) and (4) while the same reaction of alpha-(arylthio)enamides (6) and (12) was found to afford-five-membered lactams (7) and (13) as major products. A novel total synthesis of (+/-)-polyzonimine (18b) was accomplished by applying the newly found reductive photocyclization of alpha-(naphthylthio)enamide leading to the formation of five-membered lactams.

  DOI：

  10.3987/com-93-6465

文献信息

• COMPLEX CHEMICAL COMPOUND, SYNTHESIS AND VARIOUS APPLICATIONS OF SAID COMPOUND
  申请人：——

  公开号：US20020055185A1

  公开（公告）日：2002-05-09

  The invention concerns a complex chemical compound comprising a solid carrier and at least a conjugate consisting of an organic polymer and a plurality of priming biomers. The invention also concerns the synthesis of said chemical compound for biopolymer synthesis and the use of said complex chemical compound after synthesis as ligand for amplifying or detecting and/or capturing target molecules.

  本发明涉及一种复合化合物，该化合物包括一种固体载体和至少一种由有机聚合物和多种起始生物体组成的共轭物。本发明还涉及用于生物聚合物合成的所述化合物的合成，以及合成后的所述复合化合物作为配体用于放大或检测和/或捕获目标分子。
• Photocyclization of Enamides. 38. Reductive Photocyclization of a-(Methylthio)- and a-(Arylthio)enamides
  作者：Takeaki Naito、Hiromi Tanada、Yumiko Suzuki、Haruko Saito、Toshiko Kiguchi、Ichiya Ninomiya

  DOI：10.3987/com-93-6465

  日期：——

  Reductive photocyclization of alpha-(methylthio)enamide (2) gave exclusively six-membered lactams (3) and (4) while the same reaction of alpha-(arylthio)enamides (6) and (12) was found to afford-five-membered lactams (7) and (13) as major products. A novel total synthesis of (+/-)-polyzonimine (18b) was accomplished by applying the newly found reductive photocyclization of alpha-(naphthylthio)enamide leading to the formation of five-membered lactams.