2-(1H-imidazol-2-yl)-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1H-imidazol-2-yl)-1,3-oxazole
• 化学式: C₆H₅N₃O
• mdl: MFCD08668956
• 分子量: 135.12
• InChiKey: RXOBGOMYLRZUPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHOD OF CYCLIC COMPOUNDS PRODUCTION IN OLEFINE METATHESIS REACTION AND USE OF RUTHENIUM CATALYSTS IN PRODUCTION OF CYCLIC OLEFINS IN OLEFINE METATHESIS REACTION<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉS CYCLIQUES DANS UNE RÉACTION DE MÉTATHÈSE D'OLÉFINES ET UTILISATION DE CATALYSEURS AU RUTHÉNIUM DANS LA PRODUCTION D'OLÉFINES CYCLIQUES DANS UNE RÉACTION DE MÉTATHÈSE D'OLÉFINES
  申请人：UNIV WARSZAWSKI

  公开号：WO2018197963A1

  公开（公告）日：2018-11-01

  The invention relates to a method for the preparation of cyclic compounds in the metathesis of olefins from acyclic dienes comprising terminal and/or non-terminal C=C double bonds; the invention also relates to the use of homogeneous ruthenium complexes and homogeneous ruthenium complexes deposited on a solid support as catalysts and/or pre-catalysts for the preparation of cyclic olefins in olefin metathesis reactions. Formula (I)

  本发明涉及一种在非环状二烯烃的烯烃复分解中制备环状化合物的方法，所述非环状二烯烃包含端部和非端部的C=C双键；本发明还涉及将均相钌络合物和负载在固体载体上的均相钌络合物作为催化剂和/或预催化剂用于烯烃复分解反应中制备环状烯烃。公式（I）
• 2-BENZOYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：PEYRONEL Jean-Francois

  公开号：US20100317687A1

  公开（公告）日：2010-12-16

  Compounds of formula (I) in which: X, R 1 , R 2 , R 3 , and R 4 are as defined in the disclosure, or an acid addition salt thereof; and therapeutic use thereof.

  其中： X，R1，R2，R3和R4如披露中所定义的化合物的公式（I），或其酸盐；以及其治疗用途。
• [EN] 4-AMINOMETHYL BENZAMIDINE DERIVATIVES AND THEIR USE AS FACTOR VIIIA INHIBITORS<br/>[FR] DERIVES DE 4-AMINOMETHYL BENZAMIDINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DU FACTEUR VIIA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2006027135A1

  公开（公告）日：2006-03-16

  The invention is concerned with novel 4-aminomethyl benzamidine derivatives of formula (I) wherein Ar and X are as defined in the description and in the claims, as well as prodrugs and pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.

  这项发明涉及新颖的式(I)的4-氨甲基苯甲酰胺衍生物，其中Ar和X如描述和索赔中定义，以及它们的前药和药学上可接受的盐。这些化合物抑制由VIIa因子和组织因子诱导的凝血因子Xa、IXa和凝血酶的形成，并可用作药物。
• [EN] DIALKYL COMPLEXES OF GALLIUM AND INDIUM AND THEIR USE FOR PREPARATION OF POLYLACTIDE-PHARMACEUTICALLY ACTIVE COMPOUND CONJUGATES AND FOR IMMORTAL RING-OPENING POLYMERIZATION OF HETEROC CLIC MONOMERS<br/>[FR] COMPLEXES DIALKYLIQUES DE GALLIUM ET D'INDIUM ET LEUR UTILISATION POUR LA PRÉPARATION DE CONJUGUÉS DE COMPOSÉS PHARMACEUTIQUEMENT ACTIFS DE POLYLACTIDE ET POUR LA POLYMÉRISATION PAR OUVERTURE DE CYCLE IMMORTELLE DE MONOMÈRES HÉTÉROCYCLIQUES
  申请人：UNIV WARSZAWSKI

  公开号：WO2018134800A1

  公开（公告）日：2018-07-26

  The object of the invention are dialkyl complexes of gallium and indium having general formula I: and their use for preparing polylactide-pharmaceutically active compound conjugates and for immortal ring-opening polymerisation of heterocyclic monomers, especially in the polymerisation of lactide.

  该发明的对象是具有一般式I的镓和铟的二烷基配合物，以及它们用于制备聚乳酸-药用活性化合物共轭物和对杂环单体的不朽开环聚合，特别是在乳酸聚合中的应用。
• [EN] MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION<br/>[FR] BENZIMIDAZOLES CONTENANT DU MORPHOLINYLE EN TANT QU'INHIBITEURS DE LA REPLICATION DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：TIBOTEC PHARM LTD

  公开号：WO2005058871A1

  公开（公告）日：2005-06-30

  The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; Rl is Ar1 or a monocyclic or bicyclic heterocycle Q is R7, pyrrolidinyl substituted with R7, piperidinyl substituted with R7 or homopiperidinyl substituted with R7; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted Cl-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4), N(R4aR4)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2Cl-6alkyloxy, carboxyl, Cl-6alkyloxycarbonyl, or -C(=Z)Ar2; and the other one of R2a and R3a is hydrogen; in case R2a is different from hydrogen then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen; in case R3a is different from hydrogen then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.

  本发明涉及含有对呼吸道合胞病毒复制具有抑制活性的吗啉基苯并咪唑的化合物，其具有式（I），一种前药、N-氧化物、加合盐、季铵盐、金属配合物或其立体化异构体，其中G是直键或可选择地取代的C1-10烷二基；R1是Ar1或单环或双环杂环；Q是R7，R7取代的吡咯烷基、R7取代的哌啶基或R7取代的同构异哌啶基；R2a和R3a中的一个选自卤素、可选择单取代或多取代的Cl-6烷基、可选择单取代或多取代的C2-6烯基、硝基、羟基、Ar2、N(R4aR4)、N(R4aR4)磺酰基、N(R4aR4b)羰基、C1-6烷氧基、Ar2氧基、Ar2Cl-6烷氧基、羧基、Cl-6烷氧羰基或-C(=Z)Ar2；R2a和R3a中的另一个是氢；如果R2a与氢不同，则R2b是氢、C1-6烷基或卤素，R3b是氢；如果R3a与氢不同，则R3b是氢、C1-6烷基或卤素，R2b是氢。还涉及其制备以及包含这些化合物的组合物，以及其作为药物的用途。