Anserin | 331-38-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Anserin
• 英文别名: Ophidin；N^α-β-alanyl-1-methyl-histidine；2-(3-Aminopropanoylamino)-3-(1-methylimidazol-4-yl)propanoic acid
• CAS: 331-38-4
• 化学式: C₁₀H₁₆N₄O₃
• 分子量: 240.262
• InChiKey: SLRNWACWRVGMKD-UHFFFAOYSA-N

物化性质

• 溶解度：
  甲醇（微溶）、水（微溶）
• 沸点：
  611.3±55.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2933290090

文献信息

• Stable aqueous compositions comprising amide-protected bioactive creatine species and uses thereof
  申请人：Owoc, John H.

  公开号：EP2377578A1

  公开（公告）日：2011-10-19

  The present invention provides amide-protected creatine molecules and compositions, containing one or more bioactive forms of creatine in aqueous compositions, wherein bioactive forms of creatine do not appreciably degrade into creatinine. Also provided are various beneficial effects of administering aqueous compositions having at least one amide-protected creatine molecule.

  本发明提供了酰胺保护的肌酸分子和组合物，其中包含一种或多种生物活性形式的肌酸在水性组合物中，其中生物活性形式的肌酸不会明显降解为肌酸酐。同时提供了在至少含有一种酰胺保护的肌酸分子的水性组合物中给予的各种有益效果。
• Stable Aqueous Compositions Comprising Amide-Protected Bioactive Creatine Species and Uses Thereof
  申请人：Owoc John H.

  公开号：US20110251280A1

  公开（公告）日：2011-10-13

  The present invention provides amide-protected creatine molecules and compositions, containing one or more bioactive forms of creatine in aqueous compositions, wherein bioactive forms of creatine do not appreciably degrade into creatinine. Also provided are various beneficial effects of administering aqueous compositions having at least one amide-protected creatine molecule.

  本发明提供了酰胺保护的肌酸分子和组合物，其中含有一种或多种生物活性形式的肌酸在水性组合物中，其中生物活性形式的肌酸不会明显降解为肌酸酐。还提供了在至少含有一种酰胺保护的肌酸分子的水性组合物中施用的各种有益效果。
• Antifatigue composition
  申请人：YAIZU SUISANKAGAKU INDUSTRY CO., LTD.

  公开号：US20020103244A1

  公开（公告）日：2002-08-01

  An antifatigue composition by which muscular fatigue or the like during or after exercise can be reduced, is obtained by incorporating an imidazole compound obtainable from extracts of fishes, shellfishes, fowl, flesh or the like, as an active ingredient. In the antifatigue composition, the imidazole compound is preferably at least one selected from the group consisting of histidine, anserine, carnosine and valenine, and salts thereof. It is further preferred to contain D-ribose as an active ingredient. By orally ingesting the antifatigue composition of the present invention, the lactic acid amount in plasma during or after exercise can be kept low, and therefore the fatigue of muscles by exercise can be controlled, and as a result, effects for improving the ability of exercise can be expected.

  一种抗疲劳组合物，可通过将从鱼类、贝类、禽肉、肉类等提取物中获得的咪唑化合物作为活性成分，以减少运动期间或运动后的肌肉疲劳等。在抗疲劳组合物中，咪唑化合物最好是来自组中的组氨酸、鹅肌肉肽、肌肉肽和缬氨酸及其盐中至少一种。进一步最好含有D-核糖作为活性成分。通过口服本发明的抗疲劳组合物，可将运动期间或运动后血浆中的乳酸含量保持较低，从而控制运动引起的肌肉疲劳，从而预期能够提高运动能力。
• Salts of sulfodehydroabietic acid and treatment of gastro-intestinal diseases
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0078152A1

  公开（公告）日：1983-05-04

  A pharmaceutically acceptable salt of sulfodehydroabietic acid of the formula: for use in the therapeutic treatment or prophylaxis of a gastro-intestinal disease and a salt of sulfodehydro-abietic acid of the formula: with lithium, potassium, magnesium, calcium, aluminium, aluminium hydroxide, an alkyl(C1-5)amine, di-alkyl(C1-5) amine, tri-alkyl(C1-5)amine, cycloalkyl(C3-6)amine, di-alkyl (C1-5)amino-alkyl(C1-5)amine, alkoxy(C1-5)-alkyl(C1-5)amine, hydroxy-alkyl(C1-5)amine, alkylene (C2-6)diamine, aralkyl (C7-8amine, alkyl(C1-6) N-piperidinoacetyl-p-aminobenzoate, alkyl(C1-5) N-prolyl-p-aminobenzoate, alkyl(C1-5) N-pipecolyl-p-amino-benzoate, morpholine, piperazine, 3-(3,4-dihydroxyphenyl)-8,8-dimethyl-1,8-diazoniaspiro[4.5]decane, 1-(2-dimethyl-aminoethyl)-4-phenyl-2-pyrrolidone, homocysteine thiolactone, an a-amino acid of the formula: wherein R' is amino, guanidino, carbamoyl, dimethylthionia, 4-imidazolyl, mercapto or methylthio, R2 is hydroxy, alkoxy(C1-5), amino, alkyl(C1-8)amino, di-alkyl(C1-5)amino, cycloalkyl-(C3-6)amino or p-alkoxy(C1-5) anilino, and A is straight alkylene (C2-5), an ω-amino acid of the formula: wherein R3 is hydroxy or alkoxy(C1-5) and B is straight alkylene(C1-5) (the alkylene being optionally substituted with phenyl), or carnosine.

  一种式硫代脱氢松香酸的药学上可接受的盐： 用于胃肠道疾病的治疗或预防的硫代脱氢松香酸和式..： 锂、钾、镁、钙、铝、氢氧化铝、烷基(C1-5)胺、二烷基(C1-5)胺、三烷基(C1-5)胺、环烷基(C3-6)胺、二烷基(C1-5)胺-烷基(C1-5)胺、烷氧基(C1-5)-烷基(C1-5)胺、羟基烷基(C1-5)胺、烷基（C2-6）二胺、芳基（C7-8）胺、N-哌啶乙酰基对氨基苯甲酸烷基（C1-6）、N-脯氨酰基对氨基苯甲酸烷基（C1-5）、N-哌啶基对氨基苯甲酸烷基（C1-5）、N-哌啶基对氨基苯甲酸烷基（C1-5）、吗啉、哌嗪、3-（3,4-二羟基苯基）-8,8-二甲基-1,8-二氮杂螺[4.5]癸烷、1-(2-二甲基-氨基乙基)-4-苯基-2-吡咯烷酮、同型半胱氨酸硫内酯、式中的 a-氨基酸： 其中 R'是氨基、胍基、氨基甲酰基、二甲硫氨基、4-咪唑基、巯基或甲硫基，R2 是羟基、烷氧基（C1-5）、氨基、烷基（C1-8）氨基、二烷基（C1-5）氨基、环烷基-（C3-6）氨基或对烷氧基（C1-5）苯胺基，A 是直亚烷基（C2-5），式中ω-氨基酸： 其中 R3 是羟基或烷氧基（C1-5），B 是直亚烷基（C1-5）（亚烷基可选择被苯基取代），或肌肽。
• METHOD FOR PRODUCING MICROCAPSULE USING SOLID FAT
  申请人：Kaneka Corporation

  公开号：EP2218446A1

  公开（公告）日：2010-08-18

  A method for production of fine microcapsules which encapsulate a hydrophilic bioactive substance at a high content and can be used in wide range of applications such as foods and medical drugs, which method enabling efficient industrial production, is provided. A method for production of S/O type microcapsules including the steps of: (1) emulsifying and dispersing a mixture of a solid fat and an aqueous solution containing a hydrophilic bioactive substance at a temperature of at least the melting point of the solid fat to obtain a W/O emulsion; (2) removing moisture in the W/O emulsion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O suspension; (3) adding the S/O suspension into an aqueous phase containing at least one selected from a surfactant (B), a thickening agent and a hydrophilic organic solvent, and permitting liquid droplet dispersion at a temperature of at least the melting point and lower than the boiling point of the solid fat to obtain an S/O/W emulsion; and (4) cooling the S/O/W emulsion to lower than the melting point of the solid fat to harden the solid fat, and further removing the moisture at a temperature lower than the melting point of the solid fat.

  本发明提供了一种生产精细微胶囊的方法，这种微胶囊能高含量地封装亲水性生物活性物质，可广泛应用于食品和医疗药品等领域，该方法可实现高效的工业化生产。生产 S/O 型微胶囊的方法包括以下步骤：(1) 在至少为固体脂肪熔点的温度下，乳化和分散固体脂肪和含有亲水性生物活性物质的水溶液的混合物，得到 W/O 型乳液；(2) 在至少为固体脂肪熔点且低于其沸点的温度下，除去 W/O 型乳液中的水分，得到 S/O 型悬浮液；(3) 将 S/O 悬浮液加入含有至少一种选自表面活性剂 (B)、增稠剂和亲水性有机溶剂的水相中，并允许液滴在至少熔点且低于固体脂肪沸点的温度下分散，得到 S/O/W 乳液；以及 (4) 将 S/O/W 乳液冷却至低于固体脂肪熔点，使固体脂肪变硬，并在低于固体脂肪熔点的温度下进一步去除水分。