kaempferol-3-O-rhamnoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: kaempferol-3-O-rhamnoside
• 英文别名: 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxychromen-4-one
• 化学式: C₂₁H₂₀O₁₀
• 分子量: 432.384
• InChiKey: SOSLMHZOJATCCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• FRACTION OFZANTHOXYLUM PIPERITUM
  申请人：Mecox Curemed Co., Ltd.

  公开号：EP3698805A1

  公开（公告）日：2020-08-26

  The present invention relates to a composition for pain, containing a fraction obtained by solvent fractionation of a Zanthoxylum piperitum leaf extract. More specifically, a solvent fraction isolated from Zanthoxylum piperitum leaves suppresses all of pain, inflammation and arthritis in a pain-induced animal model, an inflammation-induced model and an arthritis-induced model and, with respect to molecular markers related thereto, exhibits very excellent expression and suppression patterns, thereby being usable in a pharmaceutical composition that is very effective in the treatment of pain- and inflammation-based arthritis.

  本发明涉及一种治疗疼痛的组合物，其中含有一种通过对 Zanthoxylum piperitum 叶提取物进行溶剂分馏获得的馏分。更具体地说，从Zanthoxylum piperitum叶中分离出的溶剂馏分可抑制疼痛诱导动物模型、炎症诱导模型和关节炎诱导模型中的所有疼痛、炎症和关节炎，并且在与之相关的分子标志物方面，表现出非常出色的表达和抑制模式，从而可用于药物组合物，对治疗疼痛和炎症性关节炎非常有效。
• EXTRACT OF CERCIS CHINENSIS HAVING ANTI-OXIDANT ACTIVITY AND ANTI-AGING ACTIVITY, AND COSMETICAL COMPOSITION CONTAINING THE EXTRACT FOR ANTI-OXIDATION, SKIN-AGING PROTECTION AND WRINKLE IMPROVEMENT
  申请人：NA Min Kyun

  公开号：US20080187610A1

  公开（公告）日：2008-08-07

  The present invention relates to extract of Cercis chinensis having anti-oxidant activity and anti aging activity containing compound of chemical formula 1 to chemical formula 20, and cosmetical composition for anti-oxidation, skin-aging protection and wrinkle improvement containing the extract as effective ingredient. The extract of present invention having protective effect on oxidative damage and skin damage, and inhibitory effect on age-dependent telomere shortening, so it can effectively used as skin-aging protection cosmetic.
• SYNTHESIS AND IDENTIFICATION OF NOVEL RSK-SPECIFIC INHIBITORS
  申请人：Hecht Sidney M.

  公开号：US20120245112A1

  公开（公告）日：2012-09-27

  A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.
• US7763287B2
  申请人：——

  公开号：US7763287B2

  公开（公告）日：2010-07-27
• US9040673B2
  申请人：——

  公开号：US9040673B2

  公开（公告）日：2015-05-26