Cyclohexadepsipeptid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Cyclohexadepsipeptid
• 英文别名: Enniatin A；(3S)-3r,9c,15c-tri-(S)-sec-butyl-6t,12t,18t-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triaza-cyclooctadecane-2,5,8,11,14,17-hexaone；cyclo-(D-2-hydroxy-3-methyl-butyryl->N-methyl-L-isoleucyl->D-2-hydroxy-3-methyl-butyryl->N-methyl-L-isoleucyl->D-2-hydroxy-3-methyl-butyryl->N-methyl-L-isoleucyl)；baccatin A；3,9,15-tri(butan-2-yl)-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
• 化学式: C₃₆H₆₃N₃O₉
• 分子量: 681.911
• InChiKey: TWHBYJSVDCWICV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  48
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  140
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• MUCOUS LAYER-ADHESIVE POLY-r-GLUTAMIC ACID NANOMICELLES AND DRUG DELIVERY SYSTEM USING SAME
  申请人：BIOLEADERS CORPORATION

  公开号：US20160193348A1

  公开（公告）日：2016-07-07

  The present invention relates to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, and more particularly, to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl groups are substituted with an amine group, a preparation method thereof, and a drug delivery system employing the mucous membrane-adhesive property of the nanomicelles. According to the present invention, the nanomicelle drug delivery system based on poly-gamma-glutamic acid that is a natural biopolymer can be used for the delivery of a drug to mucous membranes to thereby increase the in vivo stability and effectiveness of the drug.

  本发明涉及由脂溶性化合物和聚γ-谷氨酸复合物组成的纳米胶束，其中部分羧基被胺基取代，更具体地，涉及由脂溶性化合物和聚γ-谷氨酸复合物组成的纳米胶束，其中部分羧基被胺基取代，以及其制备方法和利用纳米胶束的粘膜粘附性质的药物传递系统。根据本发明，基于天然生物聚合物聚γ-谷氨酸的纳米胶束药物传递系统可用于将药物传递至粘膜，从而增加药物在体内的稳定性和有效性。
• Tocopherol-modified therapeutic drug compounds
  申请人：Zhang Yuehua

  公开号：US20050096340A1

  公开（公告）日：2005-05-05

  Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.

  生育酚修饰的治疗药物化合物；包括这些化合物的乳剂、微乳剂和胶束配方；制备这些化合物和配方的方法；给药这些化合物和配方的方法；以及使用这些化合物和配方治疗疾病的方法。
• [EN] SOLID NANOPARTICLE FORMULATION OF WATER INSOLUBLE PHARMACEUTICAL SUBSTANCES WITH REDUCED OSTWALD RIPENING<br/>[FR] FORMULATION DE NANOPARTICULES SOLIDES DE SUBSTANCES PHARMACEUTIQUES INSOLUBLES DANS L'EAU AVEC MÛRISSEMENT D'OSTWALD RÉDUIT
  申请人：SELVARAJ RAJ

  公开号：WO2019055525A1

  公开（公告）日：2019-03-21

  The present invention provides pharmaceutical compositions composed of solid nanoparticles dispersed in aqueous medium of substantially water insoluble pharmaceutical substances with reduced Ostwald ripening.

  本发明提供了由固体纳米颗粒组成的药物组合物，分散在基本不溶于水的药物物质的水性介质中，并减少了奥斯瓦尔德成核。
• [EN] TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS<br/>[FR] COMPOSES MEDICAMENTEUX A BASE DE TOCOPHEROL MODIFIE
  申请人：SONUS PHARMA INC

  公开号：WO2005042539A1

  公开（公告）日：2005-05-12

  Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.

  维生素E改性治疗药物化合物；包括化合物的乳液、微乳液和胶束制剂；制备化合物和制剂的方法；使用化合物和制剂进行治疗的方法。
• TOCOPHEROL-MODIFIED THERAPEUTIC DRUG COMPOUNDS
  申请人：Zhang Yuehua

  公开号：US20080045559A1

  公开（公告）日：2008-02-21

  Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.

  维生素E改性治疗药物化合物；包括该化合物的乳液、微乳液和胶束制剂；制备该化合物和制剂的方法；给予该化合物和制剂的方法；以及使用该化合物和制剂治疗疾病的方法。