10-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5-hydroxy-2-(4-hydroxy-phenyl)-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 10-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5-hydroxy-2-(4-hydroxy-phenyl)-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one
• 英文别名: 10-[5-(5,7-Dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5-hydroxy-8-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one
• 化学式: C₃₅H₂₄O₁₀
• 分子量: 604.57
• InChiKey: UKUSZBXLMJFGPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  45
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  163
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 10-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5-hydroxy-2-(4-hydroxy-phenyl)-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one 以 乙醚 为溶剂， 以80%的产率得到5-Hydroxy-10-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxy-phenyl]-2-(4-methoxy-phenyl)-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one
  参考文献：
  名称：

  Biflavonoids of Calophyllum venulosum

  摘要：

  Four new biflavonoids [pyranoamentoflavone 7,4"'-dimethyl ether (1), pyranoamentoflavone 7,4'-dimethyl ether (2), 6"-(3-methyl-2-butenyl)amentoflavone (8), and 6"-(2-hydroxy-3-methyl-3-butenyl)amentoflavone (4)], as well as three known biflavonoids, [pyranoamentoflavone (5a), amentoflavone (6), and 2,3-dihydroamentoflavone (7)] have been isolated from the leaves of Calophyllum venulosum. The structures of the new compounds were established by spectroscopic data and chemical modification.

  DOI：

  10.1021/np970303f

文献信息

• Biflavonoids of <i>Calophyllum venulosum</i>
  作者：Shu-Geng Cao、Keng-Yeow Sim、Swee-Hock Goh

  DOI：10.1021/np970303f

  日期：1997.12.1

  Four new biflavonoids [pyranoamentoflavone 7,4"'-dimethyl ether (1), pyranoamentoflavone 7,4'-dimethyl ether (2), 6"-(3-methyl-2-butenyl)amentoflavone (8), and 6"-(2-hydroxy-3-methyl-3-butenyl)amentoflavone (4)], as well as three known biflavonoids, [pyranoamentoflavone (5a), amentoflavone (6), and 2,3-dihydroamentoflavone (7)] have been isolated from the leaves of Calophyllum venulosum. The structures of the new compounds were established by spectroscopic data and chemical modification.