ethyl 9-aminononanoate hydrochloride | 111823-29-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 9-aminononanoate hydrochloride
• 英文别名: Ethyl 9-aminononanoate;hydrochloride
• CAS: 111823-29-1
• 化学式: C₁₁H₂₃NO₂*ClH
• 分子量: 237.77
• InChiKey: OAOMIYCCTRBZOI-UHFFFAOYSA-N

物化性质

• 熔点：
  129-132 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 9-aminononanoate hydrochloride 在 一水合肼 、 N,N-二异丙基乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 25.0h， 生成 N-(9-hydrazino-9-oxononyl)-3,4,5-trimethoxybenzamide
  参考文献：
  名称：

  Novel Heterobivalent Tacrine Derivatives as Cholinesterase Inhibitors with Notable Selectivity Toward Butyrylcholinesterase

  摘要：

  Two series of novel heterobivalent tacrine derivatives were synthesized. A trimethoxy substituted benzene was linked to the tacrine moiety by a hydrazide-based linker. The compounds were evaluated as cholinesterase inhibitors, and trimethoxybenzoic acid derivatives with 11- or 12-atom spacers were the most potent inhibitors of human acetylcholinesterase. The inhibitors showed a surprising selectivity toward human butyrylcholinesterase, where several trimethoxyphenylpropionic acid derivatives had IC50 values less than 250 mu M.

  DOI：

  10.1021/jm060742o
• 作为产物：
  描述：

  癸二酸氢乙酯 在 盐酸 、 二苯基膦叠氮化物 、 三乙胺 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 反应 14.0h， 生成 ethyl 9-aminononanoate hydrochloride
  参考文献：
  名称：

  Novel Heterobivalent Tacrine Derivatives as Cholinesterase Inhibitors with Notable Selectivity Toward Butyrylcholinesterase

  摘要：

  Two series of novel heterobivalent tacrine derivatives were synthesized. A trimethoxy substituted benzene was linked to the tacrine moiety by a hydrazide-based linker. The compounds were evaluated as cholinesterase inhibitors, and trimethoxybenzoic acid derivatives with 11- or 12-atom spacers were the most potent inhibitors of human acetylcholinesterase. The inhibitors showed a surprising selectivity toward human butyrylcholinesterase, where several trimethoxyphenylpropionic acid derivatives had IC50 values less than 250 mu M.

  DOI：

  10.1021/jm060742o

文献信息

• [EN] CARBOXYLIC DIARYTHIAZEPINEAMINES AS MIXED MU-AND DELTA-OPIOID RECEPTOR AGONISTS<br/>[FR] DIARYTHIAZÉPINAMINES CARBOXYLIQUES EN TANT QU'AGONISTES MIXTES DE RÉCEPTEUR D'OPIOÏDE MU ET DELTA
  申请人：UNIV COLUMBIA

  公开号：WO2018170275A1

  公开（公告）日：2018-09-20

  The present invention provides a compound having the structure:, or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with a pain, a depressive disorder, a mood disorder, an anxiety disorder, borderline personality disorder, opioid addiction, or opioid withdrawal symptoms by administering the compound to the subject.

  本发明提供一种具有以下结构的化合物，或其药用可接受的盐或酯，以及通过向受到疼痛、抑郁障碍、情绪障碍、焦虑障碍、边缘人格障碍、阿片类成瘾或阿片类戒断症状困扰的对象施用该化合物的方法。
• 2-Pyridylcarboxamides which inhibit arachidonic acid release
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04555520A1

  公开（公告）日：1985-11-26

  2-Pyridylcarboxamides are provided having the structure ##STR1## wherein n is 1 to 10; R is hydrogen, lower alkyl, alkali metal or an amine salt; and R.sup.1 is C.sub.6 -C.sub.20 alkyl, C.sub.6 -C.sub.20 alkenyl, C.sub.6 to C.sub.20 alkoxy or phenyl. These compounds are useful as inhibitors of arachidonic acid release and as such are useful as antiallergy agents.

  提供具有结构##STR1##的2-吡啶基羧酰胺，其中n为1至10；R为氢、低碳烷基、碱金属或胺盐；R1为C6-C20烷基、C6-C20烯基、C6至C20烷氧基或苯基。这些化合物可用作阿拉基多酸释放抑制剂，因此可用作抗过敏药物。
• [EN] CARBOXYLIC DIARYLTHIAZEPINEAMINES AND USES THEREFOR<br/>[FR] DIARYLTHIAZÉPINEAMINES CARBOXYLIQUES ET LEURS UTILISATIONS
  申请人：KURES INC

  公开号：WO2022074589A1

  公开（公告）日：2022-04-14

  The present disclosure provides a compound having the structure: Formula (I) or a pharmaceutically acceptable salt or ester thereof, for treating or preventing a neurological disorder, including Huntington's disease, Rett syndrome, and CDKL5 disorder.

  本公开提供一种具有以下结构的化合物：公式（I）或其药学上可接受的盐或酯，用于治疗或预防神经系统疾病，包括亨廷顿病、雷特综合征和CDKL5疾病。
• Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor
  作者：Jun-ya Kato、Shigeru Korenaga、Masaru Iwakura

  DOI：10.1016/j.bmcl.2022.129083

  日期：2023.1

  TYK2 degradation activity. Degrader 5 induced TYK2 degradation without affecting the protein level of subtype kinases (JAK1, JAK2, and JAK3) in Jurkat cellular assays. Furthermore, modifying the TYK2 ligand moiety of degrader 5 yielded the more potent TYK2 degrader 37 with retained selectivity for JAKs. Our subtype-selective TYK2 degraders represent valuable chemical probes for investigating the biology

  TYK2 是近端膜结合酪氨酸激酶 JAK 家族的成员，已成为治疗自身免疫性疾病的有吸引力的靶标。在此，我们报告了一流的强效亚型选择性 TYK2 降解剂的发现。通过将已知变构TYK2抑制剂的TYK2配体与作为E3连接酶配体的VHL配体通过不同长度的烷基接头缀合，我们快速鉴定了具有中等TYK2降解活性的TYK2降解剂5 。在 Jurkat 细胞检测中，Degrader 5诱导 TYK2 降解，而不影响亚型激酶（JAK1、JAK2 和 JAK3）的蛋白质水平。此外，修饰降解剂5的 TYK2 配体部分产生了更有效的 TYK2 降解剂37 ，并保留了对 JAK 的选择性。我们的亚型选择性 TYK2 降解剂是研究 TYK2 降解生物学的有价值的化学探针。
• Potential anticancer agents. 5-(N-Substituted-aminocarbonyl)- and 5-(N-substituted-aminothiocarbonyl)-5,6,7,8-tetrahydrofolic acids
  作者：Carroll Temple、Robert D. Elliott、John A. Montgomery

  DOI：10.1021/jm00398a034

  日期：1988.3

  5-[[N-[(Ethoxycarbonyl)alkyl]amino]carbonyl] (6-9) and the corresponding aminothiocarbonyl (12-15) derivatives of 5,6,7,8-tetrahydrofolic acid were prepared as multisubstrate analogues of the substrate--cofactor adduct in the reactions catalyzed by the folate-mediated one-carbon transfer reactions. Evaluation in vitro showed that 7 (alkyl = hexyl) was cytotoxic to H.Ep.-2 cells (ED50, 4 microM) but noncytotoxic to proliferating L1210 cells. No activity was observed for 7 against the P388 leukemia in mice.