Sant-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Sant-1
• 英文别名: (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
• 化学式: C₂₃H₂₇N₅
• 分子量: 373.5
• InChiKey: FOORCIAZMIWALX-JJIBRWJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Use Of Quinolinone Derivatives As A Research Tool
  申请人：Ruat Martial

  公开号：US20130236912A1

  公开（公告）日：2013-09-12

  The present invention relates to the use of quinolinone derivatives of general formula (I), ligands of the Smo receptor or of related receptors which target a binding site of the receptor which is different from the known ligand binding sites, as research tools for identifying modulators of the Smo receptor or of related receptors, characterizing the Hedgehog signalling pathway and diagnosis; the invention also relates to kits containing said derivatives of general formula (I).

  本发明涉及通式（I）的喹啉酮衍生物的使用，这些衍生物是Smo受体或相关受体的配体，其靶向受体的结合位点不同于已知的配体结合位点，作为研究工具用于鉴定Smo受体或相关受体的调节剂，表征Hedgehog信号通路和诊断；本发明还涉及包含上述通式（I）的衍生物的试剂盒。
• METHOD FOR PRODUCING INSULIN-PRODUCING CELL USING DIHYDROINDOLIZINONE DERIVATIVES
  申请人：Tokyo Institute of Technology

  公开号：EP3998107A1

  公开（公告）日：2022-05-18

  As an approach of efficiently inducing differentiation from pluripotent stem cells into insulin-producing cells, provided is a method comprising the step of three-dimensionally culturing cells in a medium containing a dihydroindolizinone derivative.

  作为一种高效诱导多能干细胞分化为胰岛素分泌细胞的方法，提供了一种包括在含有二氢吲哚嗪酮衍生物的培养基中三维培养细胞的方法。
• Methods for production of functional beta cells
  申请人：Janssen Biotech, Inc.

  公开号：US10633635B2

  公开（公告）日：2020-04-28

  The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.

  本发明提供了将胰腺内分泌细胞分化成表达PDX1、NKX6.1、MAFA、UCN3和SLC2A的胰腺β细胞的方法。这些胰腺β细胞可通过多能干细胞的逐步分化获得。胰岛β细胞表现出与胰岛细胞相似的葡萄糖依赖性线粒体呼吸和葡萄糖刺激的胰岛素分泌。
• Treatment of demyelinating diseases
  申请人：M ET P PHARMA AG

  公开号：US10596181B2

  公开（公告）日：2020-03-24

  Described herein are methods of promoting remyelination in a subject suffering from demyelination diseases by administering to the subject a combination of steroid hormones and Hedgehog signaling pathway modulators. Also described are methods of administering the combination of drugs, wherein the combination of drugs are in compositions adapted for nasal administration.

  本文描述了通过对患有脱髓鞘疾病的受试者施用类固醇激素和刺猬信号通路调节剂的组合药物来促进其脱髓鞘再形成的方法。还描述了施用药物组合的方法，其中药物组合为适于鼻腔给药的组合物。
• Differentiation of human embryonic stem cells into pancreatic endocrine cells using thyroid hormone and/or alk5, an inhibitor of tgf-beta type 1 receptor
  申请人：Janssen Biotech, Inc.

  公开号：US10947511B2

  公开（公告）日：2021-03-16

  The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.

  本发明提供了促进多能干细胞分化为表达PDX1、NKX6.1和HB9的胰腺内胚层细胞的方法。特别是，这些方法包括用甲状腺激素（如T3）、ALK5抑制剂或两者培养4至6期细胞。