作者:Alex Salazar-Medina、Rocío Sugich-Miranda、Eli Teran-Cabanillas、Jesús Hernández、Gustavo González-Aguilar、Enrique Rudiño-Piñera、Rogerio Sotelo-Mundo、Enrique Velázquez-Contreras
DOI:10.3390/molecules18021762
日期:——
The cyclophanes 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10, 24,27,30,33-octaaza-17,40-dioxa[10.1.10.1]paracyclophane (PO) and 2,9,25,32-tetraoxo-4,7,27,30-tetrakis(carboxymethyl)-1,4,7,10,24,27,30,33-octaaza[10.1.10.1]paracyclophane (PC) were coordinated with iron to form cationic binuclear Fe(III) Fe2PO and Fe2PC complexes, respectively. Their antioxidant capacity, superoxide dismutase and peroxidase mimetic activity, as well as their toxicity toward peripheral blood mononuclear cells (PBMCs) were evaluated. Both Fe2PO and Fe2PC are interesting biomimetics with antioxidant capacity similar to that of ascorbic acid that prevent mortality in cultured PBMCs, with the potential to have bioactive and protective functions in disease animal models.
环烷 2,9,25,32-四
氧代-4,7,27,30-四(羧
甲基)-1,4,7,10, 24,27,30,33-八
氮杂-17,40-二
氧杂[10.1 .10.1]
对环芳烷 (PO) 和 2,9,25,32-四
氧代-4,7,27,30-四(羧
甲基)-1,4,7,10,24,27,30,33-八
氮杂[10.1 .10.1]
对环芳烷(
PC)与
铁配位,分别形成阳离子双核Fe(III)Fe2PO和Fe2
PC络合物。评估了它们的抗
氧化能力、超
氧化物歧化酶和
过氧化物酶模拟活性,以及对外周血单核细胞(P
BMC)的毒性。 Fe2PO 和 Fe2
PC 都是有趣的仿生剂,其抗
氧化能力与
抗坏血酸相似,可防止培养的 P
BMC 死亡,并在疾病动物模型中具有
生物活性和保护功能的潜力。