myristoyl-DL-xiThr(1)-DL-Gln-DL-Asp-Gly-DL-Asn-DL-Asp-Gly-DL-Tyr-DL-Val-(1)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: myristoyl-DL-xiThr(1)-DL-Gln-DL-Asp-Gly-DL-Asn-DL-Asp-Gly-DL-Tyr-DL-Val-(1)
• 英文别名: 2-[15-(2-amino-2-oxoethyl)-24-(3-amino-3-oxopropyl)-12-(carboxymethyl)-6-[(4-hydroxyphenyl)methyl]-28-methyl-2,5,8,11,14,17,20,23,26-nonaoxo-3-propan-2-yl-27-(tetradecanoylamino)-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-21-yl]acetic acid
• 化学式: C₅₃H₈₁N₁₁O₁₈
• 分子量: 1160.3
• InChiKey: WFOPIRXUIQRPQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  82
• 可旋转键数：
  25
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  469
• 氢给体数：
  14
• 氢受体数：
  18

文献信息

• Cyclic lipopeptide antibiotic Locillomycin (Locillomycin-A, Locillomycin-B, Locillomycin-C) and methods of making and using the same
  申请人：Luo Chuping

  公开号：US20150080292A1

  公开（公告）日：2015-03-19

  This invention provides new cyclic lipopeptide antibiotic Locillomycin (Locillomycin-A, Locillomycin-B, Locillomycin-C) that display very strong antifungal, antibacterial, antivirus activities in a variety of contexts in vitro; methods of making and using the compounds, wherein Locillomycin-A, Locillomycin-B and Locillomycin-C are derived and purified from the culture of Bacillus subtilis Bs916.