An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition.
一种具有真皮填充和组织扩张活性的可注射组合物包括:(1)一定量的
弹性蛋白,当注射到需要真皮填充和组织扩张的受试者体内时,足以实现真皮填充和组织扩张;(2)药学上可接受的载体。该组合物可进一步包含
胶原蛋白;在其他替代方案中,该组合物可进一步包含透明质酸;
弹性蛋白、
胶原蛋白和透明质酸中的一种或多种(如果存在)可进行分子内或分子间交联。不过,即使组合物中含有
胶原蛋白或透明质酸,
弹性蛋白也是主要填充物。