2-(3,4-dihydroxyphenyl)-3-methyl-3,4-dihydro-2H-chromene-5,7-diol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-dihydroxyphenyl)-3-methyl-3,4-dihydro-2H-chromene-5,7-diol
• 化学式: C₁₆H₁₆O₅
• 分子量: 288.29
• InChiKey: WTOWZADSSKQQQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Flavonoid derivative compounds and method for preparing same by depolymerization of condensed tannins
  申请人：INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

  公开号：US10030009B2

  公开（公告）日：2018-07-24

  A compound of general formula (I) in which R1, R2, R3 and R5, identical or different, each represent a hydrogen atom or a hydroxyl group, optionally protected by a protecting group. R4 represents a hydrogen atom or an —OR7 group, in which R7 represents a hydrogen atom, a protecting group or a gallate group. R6 represents a hydroxyl group, optionally protected by a protecting group. R′1, R′2, R′3 and R′4, identical or different, each represent a hydrogen atom or a substituent not comprising a mesomeric electron withdrawing group conjugated with the furan ring. A substituent from R′1, R′2, R′3 and R′4 representing the covalent bond with the pyran ring or one of the salts of same. A method for obtaining such a compound includes a step of depolymerization of condensed tannins in the presence of an acid by means of a nucleophile derived from furan.

  通式(I)的化合物，其中 R1、R2、R3 和 R5 相同或不同，各自代表氢原子或羟基，可选择受保护基保护。R4 代表氢原子或-OR7 基团，其中 R7 代表氢原子、保护基团或没食子酸基团。R6 代表羟基，可选择受保护基团的保护。R′1、R′2、R′3 和 R′4，相同或不同，各自代表一个氢原子或一个不包括与呋喃环共轭的间取电子基团的取代基。R′1、R′2、R′3和R′4中的取代基代表与吡喃环或其盐之一的共价键。获得这种化合物的方法包括在有酸存在的情况下，通过来自呋喃的亲核剂使缩合单宁解聚的步骤。
• Avocado flesh and/or skin extract rich in polyphenols and cosmetic, dermatological and nutraceutical compositions comprising same
  申请人：Laboratoires Expanscience

  公开号：US11026441B2

  公开（公告）日：2021-06-08

  The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

  本发明涉及一种富含多酚的牛油果提取物，以没食子酸当量表示，含有至少 10%（按重量计）的多酚，其中所述的多酚包含原花青素、咖啡酸和咖啡酸衍生物，以没食子酸当量表示，相对于总多酚含量（按重量计）的比例通常至少为 70%（按重量计）。本发明还涉及一种组合物，该组合物由作为活性剂的本发明提取物和合适的赋形剂组成。本发明还涉及这样一种组合物或这样一种提取物，用于预防或治疗皮肤、粘膜或身体表层增生的疾病或病理状况。最后，本发明还涉及一种用于皮肤、身体表皮或粘膜的美容护理工艺，其目的是改善皮肤、粘膜或皮肤表皮的状况或外观，该工艺包括施用此类组合物或此类提取物。
• Methods to isolate anti-microbials from fruit or seed extracts
  申请人：WiSys Technology Foundation, Inc.

  公开号：US11357811B2

  公开（公告）日：2022-06-14

  The invention provides a method of isolating one or more compounds present in fruit juice or seed extracts that have anti-microbial activity.

  本发明提供了一种方法，用于从果汁或籽提取物中分离出一种或多种具有抗微生物活性的化合物。
• NOVEL METHODS FOR PRODUCING THERMOSETTING EPOXY RESINS
  申请人：Boutevin Bernard

  公开号：US20120165429A1

  公开（公告）日：2012-06-28

  The present application relates to a method for preparing epoxy resins from a mixture of epoxidized phenolic compounds, wherein said epoxidized phenolic compounds are obtained by the epoxidation of natural phenolic compounds selected from the group comprising simple phenol, acid-phenol, coumarin, naphthoquinone, stillbenoid, flavonoid, isoflavanoid, anthocyanin, condensed tannin and hydrolyzable tannin.
• FLAVONOID DERIVATIVE COMPOUNDS AND METHOD FOR PREPARING SAME BY DEPOLYMERIZATION OF CONDENSED TANNINS
  申请人：INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

  公开号：US20170260170A1

  公开（公告）日：2017-09-14

  A compound of general formula (I) in which R 1 , R 2 , R 3 and R 5 , identical or different, each represent a hydrogen atom or a hydroxyl group, optionally protected by a protecting group. R 4 represents a hydrogen atom or an —OR 7 group, in which R 7 represents a hydrogen atom, a protecting group or a gallate group. R 6 represents a hydroxyl group, optionally protected by a protecting group. R′ 1 , R′ 2 , R′ 3 and R′ 4 , identical or different, each represent a hydrogen atom or a substituent not comprising a mesomeric electron withdrawing group conjugated with the furan ring. A substituent from R′ 1 , R′ 2 , R′ 3 and R′ 4 representing the covalent bond with the pyran ring or one of the salts of same. A method for obtaining such a compound includes a step of depolymerization of condensed tannins in the presence of an acid by means of a nucleophile derived from furan.