7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one | 62536-78-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one
• 英文别名: 7-methoxy-2-(2-methoxyphenyl)chromen-4-one；7,2'-dimethoxy flavone；7,2'-dimethoxyflavone；ST083657；7-methoxy-2-(2-methoxy-phenyl)-chromen-4-one；7-Methoxy-2-(2-methoxy-phenyl)-chromen-4-on
• CAS: 62536-78-1
• 化学式: C₁₇H₁₄O₄
• 分子量: 282.296
• InChiKey: WVWDHKIZBHIGJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one 在 三氯化铝 、 苯 作用下， 生成 7-羟基-2-(2-羟基苯基)-4H-苯并吡喃-4-酮
  参考文献：
  名称：

  Gallagher et al., Journal of the Chemical Society, 1953, p. 3770,3777

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二酚 在 盐酸 、 potassium carbonate 、 sodium hydroxide 、 zinc(II) chloride 作用下， 以 乙醚 、 乙醇 、 水 为溶剂， 生成 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one
  参考文献：
  名称：

  Inhibitory effect of flavonoids on human glutaminyl cyclase

  摘要：

  Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4' (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC) inhibitors. The efficacy investigation of these compounds was performed by spectrophotometric assessment and the structure-activity relationship (SAR) was evaluated. Molecular docking was also carried out to analyze the binding mode of the synthesized flavonoid to the active site of hQC. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2016.03.064

文献信息

• One-pot synthesis of 3-haloflavones from flavones using Oxone® and potassium halide as a halogenation reagent
  作者：Tao Peng、Gang Wang、Shouguo Zhang、Yunbo Sun、Shuchen Liu、Lin Wang

  DOI：10.1016/j.tetlet.2019.151511

  日期：2020.2

  A two-step, one-pot method has been developed for the synthesis of 3-haloflavones from the corresponding flavones. The method uses Oxone® and potassium halide to produce the active molecular halogen in situ. The solvent (methanol) then participates in the reaction to afford the 2-methoxy-3-haloflavanone derivative. After adding sodium hydroxide, the corresponding 3-haloflavone product is obtained in

  已经开发了一种两步一锅法，用于从相应的黄酮合成3-卤代黄酮。该方法使用Oxone®和卤化钾原位生成活性分子卤素。然后，溶剂（甲醇）参与反应，得到2-甲氧基-3-卤代黄烷酮衍生物。加入氢氧化钠后，以良好至优异的产率获得相应的3-卤黄酮产物。该方法提供了从相同的黄酮起始原料方便地合成3-氯，3-溴和3-碘黄酮的方法。
• Transcription factor modulating compounds and methods of use thereof
  申请人：Levy Stuart B.

  公开号：US20090131401A1

  公开（公告）日：2009-05-21

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了可用作抗感染剂的取代苯并咪唑化合物，其可降低微生物的耐药性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及其制备的药物制剂，例如用于减少抗生素耐药性和抑制生物膜的制剂。
• TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：LEVY Stuart B.

  公开号：US20110230523A1

  公开（公告）日：2011-09-22

  Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

  本发明提供了用作抗感染剂的取代苯并咪唑化合物，可以降低微生物的抗性、毒力或生长。本发明还提供了制备和使用取代苯并咪唑化合物的方法，以及制备其药物制剂，例如，在减少抗生素抗性和抑制生物膜方面的应用。
• Sulfoxide-mediated approach to flavones through one-pot Knoevenagel condensation/oxa-Michael addition/sulfoxide elimination process of β-(o-hydroxyaryl)-ketosulfone with arylaldehydes
  作者：Mei-Lin Tang、Jin-Feng Ning、Yu-Hui Li、Heyanhao Zhang、Mi Liu、Ye-Jun Dong、Jun Chang

  DOI：10.1016/j.tetlet.2022.154336

  日期：2023.2

  gram-scale synthesis of flavones is described by a one-pot straightforward sulfoxide-mediated Knoevenagel condensation/intermolecular oxa-Michael annulation/sulfoxide elimination process of β-(o-hydroxyaryl)-ketosulfones (dual nucleophile) and arylaldehydes (dual electrophile). The expeditious synthetic route sets up flavones, including the bond formation of one CO and one double CC bonds via a formal (5 + 1)

  在本文中，通过一锅法直接亚砜介导的 Knoevenagel 缩合/分子间 oxa-Michael 环化/β-(o-羟基芳基）-酮砜（双亲核试剂）和芳基醛（双亲电试剂）。快速合成路线建立了黄酮，包括通过形式 (5 + 1) 环加成形成一个 C O 键和一个双 C C 键。此外，其中，化合物70 亿可能是进一步开发药物以造福抗衰老领域的绝佳起点。
• Tire with rubber containing flavone
  申请人：THE GOODYEAR TIRE & RUBBER COMPANY

  公开号：EP1391327A1

  公开（公告）日：2004-02-25

  The invention relates to a rubber composition and a pneumatic tire having a component comprising a rubber containing the reaction product of a flavone and a methylene donor.

  本发明涉及一种橡胶组合物和充气轮胎，其成分包括含有黄酮和亚甲基供体反应产物的橡胶。